Clinical Report: The Role of Triglyceride-Glucose Index in Predicting GDM

Overview

This study investigates the association between triglyceride-glucose (TyG) levels in early and mid-pregnancy and the risk of developing gestational diabetes mellitus (GDM).

Background

Gestational diabetes mellitus (GDM) is a significant health concern for both mothers and infants, with rising prevalence rates globally. This study aims to enhance understanding of the role of TyG levels in predicting GDM risk during pregnancy.

Data Highlights

Key Findings

• 119 out of 870 participants developed GDM, resulting in a 13.68% incidence rate.
• Elevated TyG levels in early pregnancy are an independent risk factor for GDM.
• Elevated TyG levels in mid-pregnancy pose the highest risk for developing GDM.
• A greater percentage increase in TyG levels from early to mid-pregnancy is associated with GDM risk.
• Confounding factors such as age, BMI, and family history of diabetes were adjusted in the analysis.

Clinical Implications

Monitoring TyG levels in early and mid-pregnancy may provide insights for identifying women at risk for GDM.

Conclusion

The findings indicate that elevated TyG indices and their progression during pregnancy are associated with GDM risk.

Related Resources & Content

1. The Journal of Clinical Endocrinology & Metabolism, 2023 -- Variability in Gestational Diabetes and Its Association with Negative Pregnancy Outcomes: Findings from a Cohort Analysis
2. The Journal of Clinical Endocrinology & Metabolism, 2023 -- Evaluating the Feasibility of a Low-Intensity Dietary Approach to Lower Triglycerides in Gestational Diabetes: A Randomized Controlled Trial
3. The Journal of Clinical Endocrinology & Metabolism, 2023 -- Dietary Patterns Linked to Insulin and Inflammation May Better Predict Gestational Diabetes Mellitus Risk
4. Frontiers in Endocrinology, 2026 -- Early prediction of late-pregnancy hypertriglyceridemia in women with gestational diabetes: development and internal validation of a clinical risk model
5. Diabetes Care, 2026 -- Diagnosis and Classification of Diabetes: Standards of Care in Diabetes—2026
6. Frontiers, 2026 -- The correlation between triglyceride-glucose index in early pregnancy and pregnancy complications and adverse pregnancy outcomes: a systematic review and meta-analysis
7. Frontiers, 2026 -- Triglyceride-glucose index as predictor of gestational diabetes mellitus in early pregnancy: a prospective cohort study
8. Diagnosis and Classification of Diabetes: Standards of Care in Diabetes—2026
9. Early prediction of late-pregnancy hypertriglyceridemia in women with gestational diabetes
10. Frontiers | The correlation between triglyceride-glucose index in early pregnancy (<20 weeks) and pregnancy complications and adverse pregnancy outcomes: a systematic review and meta-analysis
11. Frontiers | Triglyceride-glucose index as predictor of gestational diabetes mellitus in early pregnancy: a prospective cohort study