A clinically applicable nomogram predicting non-return to work in young and middle-aged patients with acute large vessel occlusion stroke: integrating neurological function and psychosocial factors for personalized rehabilitation - Report - MDSpire

A clinically applicable nomogram predicting non-return to work in young and middle-aged patients with acute large vessel occlusion stroke: integrating neurological function and psychosocial factors for personalized rehabilitation

  • By

  • Yu Ding

  • Jingling Zhu

  • Yiling He

  • Xiuling Yang

  • Wenfei Liang

  • Kangqiang Yang

  • Xiaoling Wu

  • Guoshun Li

  • Jiasheng Zhao

  • Zhan Zhao

  • Jingyi Chen

  • Qiuxing He

  • Weimin Ning

  • June 24, 2026

  • 0 min

Share

Clinical Report: Nomogram for Predicting Non-Return to Work After Stroke

Overview

This study identifies key predictors of non-return to work (non-RTW) in young and middle-aged patients following acute ischemic stroke due to large vessel occlusion. A nomogram was developed and validated based on these predictors.

Background

Acute ischemic stroke due to large vessel occlusion significantly impacts the ability of young and middle-aged patients to return to work. Current prediction methods lack objective tools.

Data Highlights

PredictorType
Instrumental Activities of Daily Living (IADL)Independent Predictor
Admission NIHSS ScoreIndependent Predictor
Nutritional Risk Screening 2002 (NRS-2002) ScoreIndependent Predictor
Balance Impairment (Berg Balance Scale)Independent Predictor
Post-Stroke Rehabilitation (Rehab)Independent Predictor
Anxiety-Depressive State (ADS)Independent Predictor

Key Findings

  • Six independent predictors of non-RTW were identified: IADL, admission NIHSS score, NRS-2002 score, balance impairment, post-stroke rehabilitation, and anxiety-depressive state.
  • The nomogram demonstrated robust discriminative performance with an AUC of 0.858 (95% CI: 0.812–0.903).
  • Calibration curves confirmed favorable calibration between predicted and observed probabilities.
  • Decision curve analysis revealed net benefit across most threshold probabilities.
  • Approximately 40–60% of stroke survivors are non-RTW.

Clinical Implications

The developed nomogram can assist clinicians in identifying patients at high risk for non-RTW.

Conclusion

The nomogram provides a tool for predicting non-RTW in young and middle-aged AIS-LVO patients after EVT.

Related Resources & Content

  1. Author(s)/Org, Source, Year -- Title
  2. Author(s)/Org, Source, Year -- Title
  3. Author(s)/Org, Source, Year -- Title
  4. Author(s)/Org, Source, Year -- Title
  5. Author(s)/Org, Source, Year -- Title
  6. Author(s)/Org, Source, Year -- Title
  7. 2026 Guideline for the Early Management of Patients With Acute Ischemic Stroke: A Guideline From the American Heart Association/American Stroke Association
  8. Post-stroke cognitive impairment is associated with poorer return-to-work outcomes in working-aged stroke survivors: A systematic review - PubMed

Original Source(s)

A clinically applicable nomogram predicting non-return to work in young and middle-aged patients with acute large vessel occlusion stroke: integrating neurological function and psychosocial factors for personalized rehabilitation

  • by Yu Ding, Jingling Zhu, Yiling He, Xiuling Yang, Wenfei Liang, Kangqiang Yang, Xiaoling Wu, Guoshun Li, Jiasheng Zhao, Zhan Zhao, Jingyi Chen, Qiuxing He, Weimin Ning

  • June 24, 2026

Related Content

Case Report: Hybrid retrograde transcarotid stenting for common carotid artery dissection secondary to acute type A aortic dissection

Risk stratification for stroke in acute persistent vertigo: development and internal validation of a multivariable prediction model

Real-world use and impact of direct oral anticoagulants among atrial fibrillation patients with cardioembolic stroke