Clinical Report: Evaluation of the Relationship Between the Triglyceride-Glucose Index and Albuminuria
Overview
This systematic review and meta-analysis evaluated the association between the triglyceride-glucose (TyG) index and albuminuria.
Background
Albuminuria is a critical early marker of glomerular microvascular injury and is predictive of chronic kidney disease (CKD) progression. Identifying modifiable risk factors associated with albuminuria is essential for early risk stratification and intervention. The TyG index serves as a convenient surrogate for insulin resistance, which is implicated in renal injury.
Data Highlights
Study Type
Sample Size
OR (95% CI)
Cross-sectional
59,148
2.37 (1.26–4.43)
After outlier exclusion
59,148
1.61 (1.48–1.75)
Cohort
Not specified
1.19 (1.03–1.37)
Key Findings
A higher TyG index is significantly associated with albuminuria (OR = 2.37).
After excluding an outlier study, the association remained significant (OR = 1.61).
Subgroup analyses showed consistent positive correlations across various populations.
The sole cohort study indicated an increased risk of new-onset albuminuria with a higher TyG index (HR = 1.19).
Publication bias assessments revealed no significant small-study effects after excluding an outlier.
Clinical Implications
Monitoring the TyG index could assist in identifying patients at risk for albuminuria.
Conclusion
Available evidence indicates that elevated TyG index correlates with increased risk of albuminuria across different populations.
