Multidimensional therapeutic advantages of Smilax glabra (Tufuling)-containing formulae in gout: an integrated Systematic Review and network pharmacology-based prediction - Report - MDSpire
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Multidimensional therapeutic advantages of Smilax glabra (Tufuling)-containing formulae in gout: an integrated Systematic Review and network pharmacology-based prediction
Clinical Report: Therapeutic Benefits of Smilax glabra (Tufuling) Formulations in Gout
Overview
This systematic review and meta-analysis evaluated the efficacy and safety of Tufuling-containing traditional Chinese medicine (TCM) formulae for gout patients. Results indicated reductions in pain, serum uric acid, and inflammatory markers when combined with Western medicine, as reported in the included studies.
Background
Gout is a prevalent inflammatory arthritis caused by monosodium urate crystal deposition, affecting millions globally. The increasing incidence, particularly in younger populations, highlights the need for effective treatments. Traditional Chinese medicine, including herbs like Smilax glabra, offers potential therapeutic options for managing gout, especially in patients with dampness-heat accumulation, as noted in recent literature.
Data Highlights
Outcome
Tufuling + WM
WM Monotherapy
VAS Scores (Pain)
Reported lower scores
Reported higher scores
Serum Uric Acid Levels
Reported lower levels
Reported higher levels
C-Reactive Protein Levels
Reported lower levels
Reported higher levels
Erythrocyte Sedimentation Rate
Reported lower levels
Reported higher levels
Gastrointestinal Adverse Events
73 cases
161 cases
Key Findings
Tufuling-containing formulae showed reductions in pain and inflammatory markers compared to WM monotherapy, as reported in the analysis.
56 RCTs with 4,605 participants were included in the analysis.
Network pharmacology identified 49 targets for Tufuling, with key pathways involved in inflammation and metabolism.
Molecular docking predicted binding of diosgenin to PTGS2 and IL1B.
Adverse events were reported less frequently with Tufuling interventions compared to WM alone.
Clinical Implications
Clinicians should consider the reported benefits and safety profile of Tufuling-containing formulations in their treatment plans for gout.
Conclusion
The findings indicate that Tufuling-containing formulae may improve symptoms of acute gout, although further rigorous studies are necessary to confirm long-term efficacy and safety.
Federal prosecutors allege that a Florida physician and research staff fabricated clinical trial records that were submitted into database systems used to evaluate investigational drugs.
