Cerebral Oximetry in Extremely Preterm Infants: 2-Year Follow-Up of the SafeBoosC-III Randomized Clinical - Report - MDSpire

Cerebral Oximetry in Extremely Preterm Infants: 2-Year Follow-Up of the SafeBoosC-III Randomized Clinical

  • By

  • Marie Isabel Skov Rasmussen

  • Mathias L. Hansen

  • Adelina Pellicer

  • Simon Hyttel-Sørensen

  • Ebru Ergenekon

  • Tomasz Szczapa

  • Cornelia Hagmann

  • Gunnar Naulaers

  • Jonathan Mintzer

  • Monica Fumagalli

  • Gabriel Dimitriou

  • Eugene Dempsey

  • Jakub Tkaczyk

  • Siv Fredly

  • Anne M. Heuchan

  • Gerhard Pichler

  • Hans Fuchs

  • Saudamini Nesargi

  • Gitte H. Hahn

  • Salvador Piris-Borregas

  • Jan Širc

  • Miguel Alsina-Casanova

  • Martin Stocker

  • Hilal Ozkan

  • Kosmas Sarafidis

  • Nicole J. Kraus

  • Tanja Karen

  • Beata Rzepecka-Weglarz

  • Serife S. Oguz

  • Liesbeth Thewissen

  • Luis Arruza

  • Asli C. Memisoglu

  • Ruth del Rio Florentino

  • Mariana Baserga

  • Pierre Maton

  • Juliane Schneider

  • M. Isabel de las Cuevas

  • Sofie Sommer Hedegaard

  • Pamela Zafra

  • Lars Bender

  • Sarah Farquharson

  • Agnieszka Ochoda-Mazur

  • Chantal Lecart

  • Afif El-Khuffash

  • Caitríona Ní Chathasaigh

  • Jan Miletin

  • Evangelia Papathoma

  • Zachary Vesoulis

  • Francesca Serrao

  • SafeBoosC-III Follow-Up Writing Group for the SafeBoosC-III Follow-Up Collaborator Group

  • Elisabeth Pichler-Stachl

  • Els Ortibus

  • Nancy Laval

  • Anna Oostra

  • Marie-Julie Debuf

  • Katarina Ticha

  • Zuzana Matějková

  • Alexander Scheid

  • Aikaterini Nourloglou

  • Vasiliki Kourou

  • Nicole Hilda Anagnostatou

  • Anjali Raj

  • Iyshwarya Stapleton

  • Jsun Wong

  • Jyothsna Purna

  • Camilla Fontana

  • Anna Zoraide Patria

  • Tone Nordvik

  • Roksana Malak

  • Elzbieta Rafinska-Wazny

  • Justyna Fiałkowska

  • Kasia Szczepanska

  • Paulina Gaweł

  • Iga Rupniak

  • Malaika Cordeiro Alcaine

  • Marta Teresa-Palacio

  • Maria Palomares Eraso

  • Thais Agut Quijano

  • Isabel Benavente Fernández

  • Isabel Cuellar Flores

  • Rosa Ayesa Arriola

  • Pilar Abenia

  • Claudia Knöpfli

  • Barbara Imboden

  • Cristina Borradori Tolsa

  • Myriam Bickle Graz

  • Sebnem Soysal

  • Sinem Gulcan Kersin

  • Mustafa Bostanci

  • Halime Sema Can Buker

  • Gülsüm Kadıoğlu

  • Ani Majeed

  • Trisha Marchant

  • Katelyn Hoffer

  • Amanda Duncan

  • Luc Cornette

  • Beril Yasa

  • Anja Klamer

  • Francisca Barcos-Munoz

  • Tatiana Boetti

  • Merih Cetinkaya

  • Mahmoud Montasser

  • Eleftheria Hatzidaki

  • Renata Bokiniec

  • Sylwia Marciniak

  • Lina Chalak

  • Shashidhar A. Rao

  • Iwona Sadowska-Krawczenko

  • Itziar Serrano-Viñuales

  • Barbara Krolak-Olejnik

  • Anne Mette Plomgaard

  • Bo Mølholm Hansen

  • Markus Harboe Olsen

  • Christian Gluud

  • Janus C. Jakobsen

  • Gorm Greisen

  • June 1, 2026

  • 0 min

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Long-Term Outcomes of Cerebral Oximetry in Extremely Preterm Infants

Overview

This report presents the findings from a 2-year follow-up of the SafeBoosC-III trial, which evaluated the impact of cerebral oximetry monitoring on survival and neurodevelopmental outcomes in extremely preterm infants. The study found no significant differences in outcomes between the cerebral oximetry group and the usual care group.

Background

Extremely preterm infants face high mortality rates and significant risks of neurodevelopmental disabilities. Cerebral oximetry monitoring may help detect cerebral hypoxia, potentially guiding interventions to improve outcomes. Understanding the long-term effects of such monitoring is crucial for optimizing care in this vulnerable population.

Data Highlights

No significant differences in the incidence of death or moderate/severe neurodevelopmental disability were observed between the cerebral oximetry and usual care groups at the 2-year follow-up.

Key Findings

  • The SafeBoosC-III trial randomized 1601 extremely preterm infants to assess the effects of cerebral oximetry monitoring.
  • No differences were found in the composite primary outcome of death or severe brain injury at 36 weeks’ postmenstrual age.
  • The 2-year follow-up included 1438 assessed children, showing no significant differences in long-term neurodevelopmental outcomes.
  • Monitoring cerebral oxygenation did not lead to improved survival or cognitive scores compared to usual care.
  • The study highlights the complexity of correlating neonatal brain injury with long-term neurodevelopmental disabilities.

Clinical Implications

Clinicians should be aware that cerebral oximetry monitoring in extremely preterm infants may not lead to improved long-term outcomes. Ongoing assessment of neurodevelopmental disabilities remains essential for this population.

Conclusion

The findings from the SafeBoosC-III follow-up indicate that cerebral oximetry monitoring does not significantly alter long-term survival or neurodevelopmental outcomes in extremely preterm infants compared to usual care.

Related Resources & Content

  1. New England Journal of Medicine, 2023 -- Cerebral Oximetry Monitoring in Extremely Preterm Infants
  2. European Radiology, 2025 -- Impact of Cerebellar Hemorrhage in Extremely Preterm Infants
  3. Frontiers in Pediatrics, 2026 -- The adverse effects of non-invasive high-frequency oscillatory ventilation
  4. Intensive Care Medicine, 2024 -- Assessing Quantitative Pupillometry Metrics for Neuroprognostic Evaluation
  5. Oxygen Levels in the Brain During Thoracoscopic Surgery for Long Gap Esophageal Atresia
  6. ILCOR Consensus on Science With Treatment Recommendations
  7. Cerebral Oximetry Monitoring in Extremely Preterm Infants | New England Journal of Medicine

Original Source(s)

Cerebral Oximetry in Extremely Preterm Infants: 2-Year Follow-Up of the SafeBoosC-III Randomized Clinical

  • by Marie Isabel Skov Rasmussen, Mathias L. Hansen, Adelina Pellicer, Simon Hyttel-Sørensen, Ebru Ergenekon, Tomasz Szczapa, Cornelia Hagmann, Gunnar Naulaers, Jonathan Mintzer, Monica Fumagalli, Gabriel Dimitriou, Eugene Dempsey, Jakub Tkaczyk, Siv Fredly, Anne M. Heuchan, Gerhard Pichler, Hans Fuchs, Saudamini Nesargi, Gitte H. Hahn, Salvador Piris-Borregas, Jan Širc, Miguel Alsina-Casanova, Martin Stocker, Hilal Ozkan, Kosmas Sarafidis, Nicole J. Kraus, Tanja Karen, Beata Rzepecka-Weglarz, Serife S. Oguz, Liesbeth Thewissen, Luis Arruza, Asli C. Memisoglu, Ruth del Rio Florentino, Mariana Baserga, Pierre Maton, Juliane Schneider, M. Isabel de las Cuevas, Sofie Sommer Hedegaard, Pamela Zafra, Lars Bender, Sarah Farquharson, Agnieszka Ochoda-Mazur, Chantal Lecart, Afif El-Khuffash, Caitríona Ní Chathasaigh, Jan Miletin, Evangelia Papathoma, Zachary Vesoulis, Francesca Serrao, SafeBoosC-III Follow-Up Writing Group for the SafeBoosC-III Follow-Up Collaborator Group , Elisabeth Pichler-Stachl, Els Ortibus, Nancy Laval, Anna Oostra, Marie-Julie Debuf, Katarina Ticha, Zuzana Matějková, Alexander Scheid, Aikaterini Nourloglou, Vasiliki Kourou, Nicole Hilda Anagnostatou, Anjali Raj, Iyshwarya Stapleton, Jsun Wong, Jyothsna Purna, Camilla Fontana, Anna Zoraide Patria, Tone Nordvik, Roksana Malak, Elzbieta Rafinska-Wazny, Justyna Fiałkowska, Kasia Szczepanska, Paulina Gaweł, Iga Rupniak, Malaika Cordeiro Alcaine, Marta Teresa-Palacio, Maria Palomares Eraso, Thais Agut Quijano, Isabel Benavente Fernández, Isabel Cuellar Flores, Rosa Ayesa Arriola, Pilar Abenia, Claudia Knöpfli, Barbara Imboden, Cristina Borradori Tolsa, Myriam Bickle Graz, Sebnem Soysal, Sinem Gulcan Kersin, Mustafa Bostanci, Halime Sema Can Buker, Gülsüm Kadıoğlu, Ani Majeed, Trisha Marchant, Katelyn Hoffer, Amanda Duncan, Luc Cornette, Beril Yasa, Anja Klamer, Francisca Barcos-Munoz, Tatiana Boetti, Merih Cetinkaya, Mahmoud Montasser, Eleftheria Hatzidaki, Renata Bokiniec, Sylwia Marciniak, Lina Chalak, Shashidhar A. Rao, Iwona Sadowska-Krawczenko, Itziar Serrano-Viñuales, Barbara Krolak-Olejnik, Anne Mette Plomgaard, Bo Mølholm Hansen, Markus Harboe Olsen, Christian Gluud, Janus C. Jakobsen, Gorm Greisen

  • June 1, 2026

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