Effects of Delay from Symptom Onset to Diagnosis in Infective Endocarditis: Findings from the National NIDUS Registry

By
Mads-Gustav Nebel Hvidt
Amna Alhakak
Peter Laursen Graversen
Katra Hadji-Turdeghal
Jacob Eifer Møller
Niels Eske Bruun
Kasper Karmark Iversen
Jonas Agerlund Povlsen
Claus Moser
Morten Holdgaard Smerup
Daniel Faurholt-Jepsen
Henning Bundgaard
Lauge Østergaard
Lars Køber
Emil Loldrup Fosbøl
August 31, 2026

Infection

Overview

This study investigates the impact of the interval between symptom onset and diagnosis on clinical outcomes in infective endocarditis (IE) using data from the National NIDUS Registry.

Background

Infective endocarditis (IE) is a severe condition with non-specific symptoms that can lead to diagnostic challenges. Understanding the relationship between symptom duration and diagnosis is crucial.

Data Highlights

No numerical data provided in the source material.

Key Findings

The study utilized the National Danish Endocarditis Study (NIDUS) database, covering all patients diagnosed with IE in Denmark from 2016 to 2021.
Patients were categorized based on the interval between symptom onset and diagnosis: ≤7 days, 8–29 days, and ≥30 days.
Microbial aetiology was determined through blood cultures, with various pathogens identified including Staphylococcus aureus and Streptococcus spp.
Class I surgical indications were based on the 2015 ESC guidelines.

Clinical Implications

Healthcare professionals should be aware of the potential consequences of diagnostic delays in infective endocarditis. Timely diagnosis and treatment initiation may improve patient outcomes and reduce mortality associated with this condition.

Conclusion

The findings from the NIDUS Registry highlight the importance of understanding the impact of symptom duration on the diagnosis and management of infective endocarditis.

Effects of Delay from Symptom Onset to Diagnosis in Infective Endocarditis: Findings from the National NIDUS Registry

Clinical Report: Effects of Delay from Symptom Onset to Diagnosis in Infective Endocarditis

Overview

Background

Data Highlights

Key Findings

Clinical Implications

Conclusion

Related Resources & Content

Original Source(s)

Impact of time from symptom onset to diagnosis in infective endocarditis: insights from the nationwide NIDUS registry

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