Impact of Admission Hyperglycemia and Estimated Glomerular Filtration Rate on Outcomes Following Mechanical Thrombectomy in Acute Ischemic Stroke

Overview

Revise to specify how postoperative renal function mediates the relationship between hyperglycemia and outcomes.

Background

Acute ischemic stroke is a leading cause of morbidity and mortality worldwide, with mechanical thrombectomy being a critical intervention for improving outcomes. Understanding the factors influencing recovery, such as admission hyperglycemia and renal function, is essential for optimizing treatment strategies and improving patient prognosis. This study addresses a gap in knowledge regarding how these factors interact to affect long-term outcomes.

Data Highlights

Key Findings

• Admission hyperglycemia is associated with a lower likelihood of achieving a good outcome at 6 months (OR 3.148, p < 0.001).
• Lower postoperative estimated glomerular filtration rate (post-eGFR) is linked to poorer functional outcomes (OR 0.978, p = 0.004).
• Post-eGFR mediates 25.57% of the total effect of admission hyperglycemia on long-term prognosis.
• 49.9% of patients experienced admission hyperglycemia.
• 38.0% of patients achieved a good outcome (mRS 0-2) at 6 months.

Clinical Implications

Clinicians should monitor admission hyperglycemia in acute ischemic stroke patients as it is a significant predictor of long-term outcomes. Additionally, attention to postoperative renal function may provide insights into patient prognosis and guide management strategies following mechanical thrombectomy.

Conclusion

The findings underscore the importance of managing admission hyperglycemia and monitoring renal function to improve long-term outcomes in patients undergoing mechanical thrombectomy for acute ischemic stroke.

Related Resources & Content

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3. Link Between Triglyceride-Glucose Index and Acute Kidney Injury Risk in Patients with Aneurysmal Subarachnoid Hemorrhage, 2025
4. AHA/ASA Early Management of Acute Ischemic Stroke 2026 Guidelines
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6. Fasting blood glucose-to-glycated hemoglobin ratio and functional outcomes in patients with ischemic stroke following endovascular treatment—a meta-analysis
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