A double-edged sword: the role of macrophage pyroptosis-driven cytokine storm-mediated intercellular communication in tumor progression - Report - MDSpire
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The Dual Role of Macrophage Pyroptosis-Induced Cytokine Storms in Tumor Development
Clinical Report: The Dual Role of Macrophage Pyroptosis-Induced Cytokine Storms in Tumor Development
Overview
This review explores how macrophage pyroptosis-driven cytokine storms can either promote anti-tumor immunity or facilitate tumor progression, depending on the intensity and duration of the inflammatory response.
Background
Understanding the role of pyroptosis in tumor immunity is critical as it represents a significant mechanism by which inflammation can influence cancer progression. Pyroptosis induces an inflammatory response and shapes the tumor microenvironment, affecting immune cell recruitment and activity.
Data Highlights
No specific numerical data or trial data presented in the article.
Key Findings
Pyroptosis is executed through both canonical and non-canonical pathways, leading to the release of pro-inflammatory cytokines.
Acute, moderate cytokine storms can activate anti-tumor immunity, while chronic, low-grade storms promote tumorigenesis.
Six interconnected mechanisms by which chronic cytokine storms facilitate tumor progression include genomic instability and immunosuppressive microenvironment establishment.
Pyroptosis-related biomarkers may aid in patient stratification and treatment-response prediction across various cancers.
Current therapeutic strategies include NLRP3 inhibitors and IL-1β/IL-18 blockers.
Clinical Implications
The findings indicate that modulation of macrophage pyroptosis could be a therapeutic strategy to balance anti-tumor efficacy and inflammatory toxicity.
Conclusion
Macrophage pyroptosis plays a dual role in tumor development.
