The Effects of Gastroesophageal Reflux Disease in East Asia and China from 1990 to 2021: Findings from the 2021 Global Burden of Disease Study - Report - MDSpire

The Effects of Gastroesophageal Reflux Disease in East Asia and China from 1990 to 2021: Findings from the 2021 Global Burden of Disease Study

  • By

  • Chengying Zhu

  • Zeming Le

  • Zhanjun Lu

  • Zihao Guo

  • Guo Yu

  • Zhiyuan Cheng

  • Changjie Zhao

  • Rong Wan

  • Weiliang Jiang

  • Wenqin Xiao

  • January 31, 2026

  • 0 min

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Clinical Report: The Effects of Gastroesophageal Reflux Disease in East Asia

Overview

This report examines the increasing burden of gastroesophageal reflux disease (GERD) in East Asia, particularly in China, from 1990 to 2021. The findings highlight significant trends in incidence, prevalence, and disability-adjusted life years (DALYs) associated with GERD in the region.

Background

Gastroesophageal reflux disease (GERD) is a chronic condition that can severely impact patients' quality of life and lead to serious complications such as esophagitis and Barrett’s esophagus. Understanding the epidemiological trends of GERD in East Asia is crucial for developing effective public health strategies and clinical management tailored to the region's unique demographic and cultural factors.

Data Highlights

Data from the GBD 2021 report indicate significant trends in GERD incidence and burden across East Asia from 1990 to 2021, with variations observed between countries.

Key Findings

  • GERD incidence and prevalence have shown a marked increase in East Asia, particularly in China, from 1990 to 2021.
  • Disability-adjusted life years (DALYs) associated with GERD have also risen, indicating a growing disease burden.
  • Age-standardized incidence rates (ASIR) and age-standardized DALYs rates (ASDR) were computed to facilitate cross-national comparisons.
  • The study identified significant differences in GERD burden based on age and sex demographics.
  • Future projections suggest continued increases in GERD prevalence and associated health impacts in the region.

Clinical Implications

Healthcare professionals should be aware of the rising burden of GERD in East Asia and consider region-specific factors when diagnosing and managing the disease. Implementing effective prevention and control strategies will be essential to address the increasing incidence and associated complications.

Conclusion

The findings underscore the need for heightened awareness and targeted interventions for GERD in East Asia, particularly in light of its increasing prevalence and associated health burdens.

References

  1. Global, regional and national burdens of gastroesophageal reflux disease from 1990 to 2021 and projections to 2050: a finding from the global burden of disease study 2021 | BMC Public Health | Springer Nature Link
  2. ASGE guideline on the diagnosis and management of GERD: methodology and review of evidence
  3. Trends and Burden of Gastrointestinal Cancers in Southeast Asia from 1990 to 2021 with Projections for 2050: Insights from the 2021 Global Burden of Disease Study
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  5. The Impact of Elevated Body Mass Index on Colorectal Cancer in China: Analysis from 1990 to 2021 and Projections for 2035
  6. Gastric Cancer — Assessing the Global Impact of Early-Onset Gastric Cancer: A Systematic Analysis Based on the 2019 Global Burden of Disease Study
  7. ASGE guideline on the diagnosis and management of GERD: methodology and review of evidence
  8. Dose and duration shape the efficacy of vonoprazan versus lansoprazole for erosive esophagitis: insights from meta-regression - PMC
  9. Global, regional and national burdens of gastroesophageal reflux disease from 1990 to 2021 and projections to 2050: a finding from the global burden of disease study 2021 | BMC Public Health | Springer Nature Link

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