Case Report: Giant cell reparative granuloma of the humerus and femur—two rare cases with atypical skeletal involvement - Report - MDSpire

Case Report: Giant cell reparative granuloma of the humerus and femur—two rare cases with atypical skeletal involvement

  • By

  • Fangfang Xu

  • Qian Li

  • Fei Dong

  • Chao Wang

  • July 7, 2026

  • 0 min

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Clinical Report: Uncommon Instances of Giant Cell Reparative Granuloma

Background

Giant cell reparative granuloma (GCRG) is a rare benign lesion typically found in the mandible and maxilla, with long bone involvement being exceedingly uncommon. Accurate diagnosis is crucial as GCRG can mimic other bone tumors. Understanding its clinical presentation and imaging characteristics is essential for healthcare professionals dealing with osteolytic lesions.

Data Highlights

No numerical or trial data was provided in the article.

Key Findings

  • GCRG is a benign reactive lesion often associated with trauma or surgical intervention.
  • Two cases of GCRG were reported, one in the proximal humerus and the other in the distal femur.
  • Imaging studies suggested a giant cell tumor of bone, highlighting diagnostic challenges.
  • Histopathological examination post-surgery confirmed the diagnosis of GCRG.

Clinical Implications

Healthcare professionals should consider GCRG in the differential diagnosis of osteolytic lesions, especially in patients with a history of trauma.

Conclusion

These cases highlight the importance of including GCRG in the differential diagnosis of osteolytic lesions at atypical skeletal sites.

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