Primary endoscopic nasopharyngectomy for nasopharyngeal carcinoma: systematic review & meta-analysis - Report - MDSpire

Primary endoscopic nasopharyngectomy for nasopharyngeal carcinoma: systematic review & meta-analysis

  • By

  • Siyuan Ding

  • Leo Li

  • Jenny Lee

  • Brian Mak

  • Christopher Liao

  • Andy Chan

  • Levina Li

  • Calvin Lai

  • Samuel Chow

  • Jason Chan

  • David Yeung

  • June 26, 2026

  • 0 min

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Clinical Report: Systematic Review and Meta-Analysis of Primary Endoscopic Nasopharyngectomy

Overview

This systematic review and meta-analysis evaluates the use of primary endoscopic nasopharyngectomy (pENPG) in treating primary nasopharyngeal carcinoma (pNPC).

Background

Nasopharyngeal carcinoma (NPC) is often diagnosed at advanced stages, making early-stage treatment critical. Current standard therapy for stage I NPC is intensity-modulated radiotherapy (IMRT), which can lead to significant toxicities. Exploring alternatives like pENPG is important in managing early-stage NPC.

Data Highlights

Study5-Year OS (pENPG)5-Year OS (IMRT)
Stage I NPC100%99.1%
All Tumor Stages90.6%N/A

Key Findings

  • Four studies involving 164 patients undergoing pENPG were reviewed.
  • 58% of patients had localized stage I NPC (T1N0M0).
  • Pooled 5-year overall survival (OS) for pENPG was 90.6% across all tumor stages.
  • 5-year OS for stage I NPC treated with pENPG was 100% in two studies.
  • Radiotherapy-associated toxicities were significantly reduced with pENPG.
  • The severity of surgical complications correlated with the extent of resection.

Clinical Implications

Further prospective studies are needed to validate the outcomes of pENPG in treating early-stage NPC.

Conclusion

Primary endoscopic nasopharyngectomy is evaluated as a treatment option for early-stage nasopharyngeal carcinoma.

Related Resources & Content

  1. Frontiers in Oncology, 2026 -- Efficacy, long-term survival and safety of different PD-1 inhibitors plus chemotherapy in recurrent or metastatic nasopharyngeal carcinoma: a systematic review and meta-analysis
  2. The ASCO Post, 2023 -- Role of Chemotherapy in Patients With Nonmetastatic Nasopharyngeal Carcinoma Treated With Radiotherapy
  3. Surgical Endoscopy -- Factors Influencing Metastasis and Survival Outcomes in T1 Gastric Neuroendocrine Carcinoma Patients Undergoing Endoscopic Treatment Compared to Surgical Resection
  4. JNCCN2302GLINS_proof.pdf -- NCCN Guidelines Insights review
  5. SEOM–TTCC clinical guideline for nasopharyngeal carcinoma (update 2025) | Clinical and Translational Oncology
  6. the asco post — Metabolic Subtypes of Nasopharyngeal Carcinoma and Response to Treatment
  7. NCCN Guidelines Insights
  8. SEOM–TTCC clinical guideline for nasopharyngeal carcinoma (update 2025) | Clinical and Translational Oncology | Springer Nature Link
  9. Frontiers | Primary Endoscopic Nasopharyngectomy for Nasopharyngeal Carcinoma: Systematic review & Meta-analysis

Original Source(s)

Primary endoscopic nasopharyngectomy for nasopharyngeal carcinoma: systematic review & meta-analysis

  • by Siyuan Ding, Leo Li, Jenny Lee, Brian Mak, Christopher Liao, Andy Chan, Levina Li, Calvin Lai, Samuel Chow, Jason Chan, David Yeung

  • June 26, 2026

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