Persistent disease burden despite advanced therapies in inflammatory bowel disease: a real-world patient-reported survey from Greece - Report - MDSpire

Persistent disease burden despite advanced therapies in inflammatory bowel disease: a real-world patient-reported survey from Greece

  • By

  • Charalampos Tzanetakos

  • Vasiliki-Rafaela Vakouftsi

  • George Mavridoglou

  • Andriani Angelopoulou

  • George Gourzoulidis

  • July 10, 2026

  • 0 min

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Clinical Report: Ongoing Impact of Inflammatory Bowel Disease Despite Modern Treatments

Overview

A survey of IBD patients in Greece reveals significant disease burden despite advanced therapies. Key findings include high rates of impaired quality of life, work productivity loss, and treatment dissatisfaction.

Background

Inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), is a chronic condition that significantly impacts patients' quality of life. Despite advancements in treatment options, many patients continue to experience substantial disease burden and unmet needs.

Data Highlights

FindingPercentage
Patients with active disease57.1%
Impaired quality of life76.4%
Work productivity loss30.3%
Activity impairment38.4%
Moderate-to-severe depressive symptoms~50%
Dissatisfaction with advanced therapy39.1%
Reduced adherence to therapy10.9%

Key Findings

  • 57.1% of patients reported active disease.
  • 76.4% experienced impaired quality of life.
  • 30.3% reported work productivity loss.
  • 38.4% had activity impairment.
  • 39.1% expressed dissatisfaction with their advanced therapy.

Clinical Implications

The findings indicate a need for enhanced management strategies for IBD patients to address ongoing symptoms and dissatisfaction with treatment. Clinicians should consider integrating patient-reported outcomes into routine assessments to better understand and address the multifaceted challenges faced by these patients.

Conclusion

Despite the availability of advanced therapies, the burden of IBD remains significant among patients in Greece.

Related Resources & Content

  1. Journal of Gastroenterology, 2016 -- Effects of Inflammatory Bowel Disease on the Quality of Life of Japanese Patients: Findings from a Patient Questionnaire Study
  2. The New Gastroenterologist, 2025 -- The Impact of Irritable Bowel Syndrome on Daily Activities: Insights from an AGA Survey
  3. BMC Psychiatry (Springer), 2025 -- Impact of anxiety, depression and online mindfulness on IBD patients’ quality of life: a web-based cross-sectional survey and randomized pilot study
  4. Journal of Crohn's and Colitis -- Attaining sustainability in inflammatory bowel disease
  5. ECCO-ESGAR-ESP-IBUS Guideline on Diagnostics and Monitoring of Patients with Inflammatory Bowel Disease: Part 1 | Journal of Crohn's and Colitis
  6. Systematic review and network meta-analysis: evaluating the impact of advanced therapies for moderate-to-severe ulcerative colitis on health-related quality of life - PubMed
  7. ECCO-ESGAR-ESP-IBUS Guideline on Diagnostics and Monitoring of Patients with Inflammatory Bowel Disease: Part 1 | Journal of Crohn's and Colitis | Oxford Academic
  8. Systematic review and network meta-analysis: evaluating the impact of advanced therapies for moderate-to-severe ulcerative colitis on health-related quality of life - PubMed

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