Scientific evidence of commercial artificial intelligence products for pulmonary nodule assessment on CT scans: a systematic review - Report - MDSpire

Scientific evidence of commercial artificial intelligence products for pulmonary nodule assessment on CT scans: a systematic review

  • By

  • Jasika Paramasamy

  • Asabi Leliveld

  • Jan-Willem Groen

  • Bo Willems

  • Joachim G. J. V. Aerts

  • Aad van der Lugt

  • Ties A. Mulders

  • Arlette E. Odink

  • Jacob J. Visser

  • July 15, 2026

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Clinical Report: Evaluation of Commercial AI Solutions for Assessing Pulmonary Nodules

Overview

This systematic review evaluates the efficacy of commercially available AI solutions for assessing pulmonary nodules on CT scans.

Background

Lung cancer is the leading cause of cancer-related mortality, making early diagnosis critical. The increasing volume of chest CT scans presents challenges for radiologists, including the risk of overlooking nodules. AI technologies offer potential to enhance nodule detection and analysis, but their efficacy requires thorough evaluation.

Data Highlights

No numerical data or trial results were provided in the source material.

Key Findings

  • AI technologies can automate the detection and analysis of pulmonary nodules, potentially reducing radiologist workload.
  • There is a lack of comprehensive evaluation of the real-world efficacy of commercially available AI software for lung nodule assessment.
  • The RADAR framework provides a holistic approach to evaluating AI technologies, considering technical performance and broader clinical impacts.
  • Studies included in the review must be peer-reviewed and focus on CE-marked or FDA-cleared AI applications.
  • Validation of AI software includes assessing test accuracy and its impact on clinical management and patient outcomes.

Clinical Implications

The findings emphasize the importance of rigorous evaluation of AI tools to ensure their effectiveness in clinical settings. Understanding the capabilities and limitations of these technologies is essential for their integration into routine practice.

Conclusion

The systematic review highlights the need for comprehensive assessments of AI solutions in pulmonary nodule evaluation.

Related Resources & Content

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  5. Lung-RADS® v2022, ACR, 2022 -- Lung-RADS® v2022
  6. Reduced Lung-Cancer Mortality with Low-Dose Computed Tomographic Screening, NEJM, 2011 -- Reduced Lung-Cancer Mortality with Low-Dose Computed Tomographic Screening
  7. Reporting guidelines for clinical trial reports for interventions involving artificial intelligence: the CONSORT-AI Extension, EQUATOR Network, 2021 -- Reporting guidelines for clinical trial reports for interventions involving artificial intelligence: the CONSORT-AI Extension
  8. Lung-RADS® v2022
  9. Reduced Lung-Cancer Mortality with Low-Dose Computed Tomographic Screening | New England Journal of Medicine
  10. Reporting guidelines for clinical trial reports for interventions involving artificial intelligence: the CONSORT-AI Extension | EQUATOR Network

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