Clinical Report: Safety and Effectiveness of Khapregesic® for Menopausal Symptoms

Overview

This randomized, double-blind, placebo-controlled trial evaluated Khapregesic® in 140 peri- and postmenopausal women. No significant overall group differences were observed; however, postmenopausal women showed improvements in psychological symptoms, fatigue, and sleep disturbances compared to placebo.

Background

Menopausal symptoms affect a significant proportion of women, with up to 85% experiencing various symptoms during the transition. Effective management of these symptoms is crucial, as they can impact quality of life. Khaya senegalensis, the source of Khapregesic®, has traditional uses for alleviating hormonal symptoms.

Data Highlights

No statistically significant differences were found in primary and secondary outcomes across the full cohort. However, postmenopausal women showed significant improvements in psychological symptoms (p = 0.014), fatigue (p = 0.045), and sleep disturbances (p = 0.024) when supplemented with Khapregesic®.

Key Findings

• No overall significant group differences in outcomes were observed.
• Postmenopausal women experienced significant improvements in mood and psychological symptoms compared to placebo.
• Fatigue levels decreased significantly in postmenopausal women receiving Khapregesic®.
• Improvements in sleep disturbances were noted in the postmenopausal group.
• Khapregesic® was generally well tolerated with mild gastrointestinal symptoms reported.

Clinical Implications

The findings suggest that Khapregesic® may offer benefits for postmenopausal women experiencing specific menopausal symptoms. Further research is needed to confirm these results and explore the potential for broader applications in managing menopausal symptoms.

Conclusion

While the overall study results did not show significant effects, the outcomes in postmenopausal women indicate areas for further investigation.

Related Resources & Content

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5. Recommendations | Menopause: identification and management | Guidance | NICE
6. The North American Menopause Society releases its 2023 Nonhormone Therapy Position Statement | EurekAlert!
7. An Examination into the Safety and Efficacy of Khapregesic®, a Khaya Senegalensis Preparation, on Women Experiencing Menstrual Pain and Menstrual Distress: A Randomized, Double-Blind, Placebo-Controlled Trial - PMC
8. Recommendations | Menopause: identification and management | Guidance | NICE
9. The North American Menopause Society releases its 2023 Nonhormone Therapy Position Statement | EurekAlert!
10. An Examination into the Safety and Efficacy of Khapregesic®, a Khaya Senegalensis Preparation, on Women Experiencing Menstrual Pain and Menstrual Distress: A Randomized, Double-Blind, Placebo-Controlled Trial - PMC