Correlation of Serum Progesterone Levels at Embryo Transfer with Clinical Pregnancy Outcomes in Patients from POSEIDON Group 1

Overview

This study investigates the relationship between serum progesterone levels on the day of embryo transfer and clinical pregnancy outcomes in POSEIDON Group 1 patients. High serum progesterone levels were found to be associated with lower clinical pregnancy rates, particularly in normal-weight patients.

Background

The POSEIDON classification aims to refine low prognosis strata in assisted reproductive technology (ART) by considering factors such as age and ovarian reserve. Understanding the role of serum progesterone in embryo transfer is crucial, as it influences endometrial receptivity and pregnancy outcomes. This study addresses the variability in progesterone levels and their impact on clinical pregnancy rates, which is essential for optimizing fertility treatments.

Data Highlights

Key Findings

• The 10th and 90th percentiles of serum progesterone were 9.45 ng/mL and 23.32 ng/mL, respectively.
• Clinical pregnancy rates were highest in the 9.45-23.32 ng/mL group.
• Serum progesterone levels exceeding 23.32 ng/mL were associated with a significantly lower clinical pregnancy rate (adjusted OR = 1.454, P = 0.032).
• The association between high serum progesterone and reduced pregnancy rates was confirmed through sensitivity analysis.
• In normal-weight patients, elevated serum progesterone was linked to lower clinical pregnancy rates, unlike in overweight/obese patients.

Clinical Implications

Clinicians should consider serum progesterone levels on the day of embryo transfer when planning luteal support strategies. Individualized approaches based on serum progesterone and body mass index may improve clinical outcomes in patients classified as POSEIDON Group 1.

Conclusion

The findings highlight the importance of serum progesterone levels in predicting clinical pregnancy outcomes in POSEIDON Group 1 patients, emphasizing the need for tailored treatment strategies.

Related Resources & Content

1. Author(s)/Org, Source, Year -- Title
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3. Frontiers in Endocrinology, 2023 -- Comparison of euploidy rates between progestin-primed ovarian stimulation and GnRH antagonist protocols
4. The Journal of Clinical Endocrinology & Metabolism, 2023 -- Elevated AMH Levels Correlate With Gestational Hypertension in PCOS Patients Undergoing IVF/ICSI with Fresh Embryo Transfer
5. The Journal of Clinical Endocrinology & Metabolism, 2023 -- Investigating the Function of SAA1 in Endometrial ECM Remodeling Associated with Polycystic Ovary Syndrome: Consequences for Pregnancy Outcomes
6. American Society for Reproductive Medicine, 2021 -- Diagnosis and treatment of luteal phase deficiency: a committee opinion
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9. Serum Progesterone Level on the Day of Embryo Transfer Is Not a Reliable Predictor for Frozen-Thawed Embryo Transfer Outcomes With Euploid Blastocyst Transfer: A Retrospective Cohort Study - PubMed