Clinical Report: Assessment of Coronary Microvascular Function in Sepsis Patients
Overview
This study investigates coronary microvascular dysfunction in sepsis patients with myocardial injury, revealing a significant association between impaired microvascular function and elevated hs-cTnT concentrations.
Background
Myocardial injury is prevalent in sepsis and linked to poor outcomes, yet the mechanisms remain unclear. Coronary microvascular dysfunction (CMD) is associated with myocardial injury. Understanding CMD in sepsis could provide insights into the pathophysiology of myocardial injury.
Data Highlights
No numerical data available in the provided source material.
Key Findings
Coronary microvascular function was assessed using invasive thermodilution-derived indices in sepsis patients.
Higher hs-cTnT concentrations were associated with greater impairment in microvascular function.
The study characterized the frequency and physiological phenotypes of CMD in sepsis.
Obstructive coronary artery disease (CAD) occurrence in sepsis patients with myocardial injury was evaluated.
Coronary microvascular function in sepsis was compared with a matched cohort of patients with chronic coronary syndrome.
Clinical Implications
The study emphasizes the importance of evaluating coronary microvascular function in sepsis patients with myocardial injury.
Conclusion
The investigation into coronary microvascular function in sepsis patients provides insights into the mechanisms of myocardial injury.
by Samantha Lörstad, Per Åstrand, Patrik Gille-Johnson, Yunzhang Wang, Christina Ekenbäck, Fadi Jokhaji, Felix Böhm, Patrik Hjalmarsson, Shajan Shekarestan, Tomas Jernberg, Sara Tehrani, Kambiz Shahgaldi, Jonas Persson
