Association between maternal thyroid function and adverse outcomes of pregnant women and offspring: evidence from an umbrella review - Report - MDSpire

Linking Maternal Thyroid Function to Negative Outcomes in Pregnant Women and Their Offspring: Insights from an Umbrella Review

  • By

  • Jiani Zhang

  • Yingying Chen

  • Guiqiong Huang

  • Chunyan Deng

  • Chihui Mao

  • Bingjie Li

  • Xiaodong Wang

  • Haiyan Yu

  • April 11, 2026

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Clinical Report: Linking Maternal Thyroid Function to Negative Outcomes in Pregnant Women

Overview

Expand to include specific adverse outcomes and their implications for maternal and neonatal health.

Background

Thyroid hormones are essential for metabolism and fetal development, particularly for brain maturation. Abnormal thyroid function during pregnancy can lead to significant complications for both mothers and infants. Understanding the implications of thyroid dysfunction is crucial for optimizing pregnancy management and improving maternal and neonatal health outcomes.

Data Highlights

No specific numerical data or trial data was provided in the source material.

Key Findings

  • Thyroid dysfunction during pregnancy is associated with increased risks of miscarriage, preterm delivery, and neurodevelopmental deficiencies in offspring.
  • Physiological changes in pregnancy can lead to fluctuations in thyroid hormone levels, necessitating careful monitoring.
  • Untreated hypothyroidism can result in severe complications such as placental abruption and low birth weight.
  • There is a lack of uniform standards for managing thyroid dysfunction in pregnancy, highlighting the need for individualized care.
  • Recent evidence suggests that early treatment of thyroid dysfunction may reduce adverse pregnancy outcomes.

Clinical Implications

Clinicians should prioritize monitoring thyroid function in pregnant women to prevent complications associated with thyroid dysfunction. Individualized treatment plans based on thyroid hormone levels and patient history are essential for optimizing maternal and fetal health.

Conclusion

This review underscores the importance of maintaining thyroid hormone balance during pregnancy to prevent adverse outcomes. Further research is needed to establish standardized management protocols for thyroid dysfunction in pregnant women.

Related Resources & Content

  1. American Thyroid Association 2026 Guidelines for Thyroid Disease in Preconception, Pregnancy, and Postpartum, 2026 -- Guidelines Overview
  2. Frontiers in Endocrinology — Associations between maternal thyroid hormones and neonatal outcomes during pregnancy, 2026 -- Study Overview
  3. Frontiers in Endocrinology — The association between maternal FT3/FT4 ratio in early pregnancy and adverse neonatal outcomes, 2026 -- Study Overview
  4. The Journal of Clinical Endocrinology & Metabolism — Association of Maternal Thyroglobulin With Gestational Thyroid Function and Offspring IQ and Brain Morphology, 2026 -- Study Overview
  5. Archives of Toxicology — Systematic Review of Chemical Interference with Placental Thyroid Hormone Signaling: Emphasizing Gender-Specific Outcomes
  6. American Thyroid Association 2026 Guidelines for Thyroid Disease in Preconception, Pregnancy, and Postpartum - Tim I.M. Korevaar, Angela M. Leung, Erik K. Alexander, Sofie Bliddal, Kristien Boelaert, Gabriela Brenta, Roger Chou, Rima Dhillon-Smith, Chrysoula Dosiou, Jennifer L. Eaton, Haixia Guan, Sarah J. Kilpatrick, Bente J. Lasserre, Sun Y. Lee, Spyridoula Maraka, Kara D. Meister, Lilah F. Morris-Wiseman, Caroline T. Nguyen, Elizabeth N. Pearce, Zhongyan Shan, 2026
  7. Treatment of Subclinical Hypothyroidism or Hypothyroxinemia in Pregnancy - PMC

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