Clinical Report: Porphyria Cutanea Tarda Induced by HCV in a Patient with SEC23B-Mutated CDA II

Background

Porphyria cutanea tarda is the most common porphyria and is frequently associated with chronic HCV infection. Understanding the interplay between genetic conditions like CDA II and viral infections is crucial for effective management of rare hematologic disorders.

Data Highlights

Key Findings

• The patient had SEC23B mutations leading to CDA II and developed PCT associated with HCV infection.
• Initial treatment with hydroxychloroquine was ineffective.
• Direct-acting antiviral therapy with sofosbuvir/velpatasvir resulted in undetectable HCV RNA and resolution of skin lesions.
• Ferritin levels decreased from 1,201 ng/mL to 587 ng/mL post-treatment.

Clinical Implications

Healthcare providers should consider the possibility of PCT in patients with HCV and underlying genetic conditions like CDA II.

Conclusion

This case highlights the need for further understanding of the interactions between genetic and viral factors in the management of PCT.

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