Oxidative stress markers in bipolar disorder and first-degree relatives: differential associations of ischemia-modified albumin and superoxide dismutase - Report - MDSpire
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Oxidative stress markers in bipolar disorder and first-degree relatives: differential associations of ischemia-modified albumin and superoxide dismutase
Clinical Report: Differential Relationships of IMA and SOD in Bipolar Disorder
Overview
This study evaluates the levels of ischemia-modified albumin (IMA) and superoxide dismutase (SOD) in patients with bipolar disorder (BD), their unaffected first-degree relatives (FDRs), and healthy controls (HCs).
Background
Bipolar disorder (BD) is associated with oxidative stress, which can lead to neuronal damage and inflammation. This study aims to evaluate the relationships between oxidative stress markers like IMA and SOD in BD patients, FDRs, and HCs.
Data Highlights
Group
IMA Levels
SOD Levels
BD Patients
Higher (β = 0.17, p = 0.007)
Higher (β = 0.37, p = 0.015)
FDRs
No significant difference
Higher (β = 0.41, p = 0.009)
HCs
Reference
Reference
Key Findings
IMA levels were significantly higher in BD patients compared to HCs.
No significant difference in IMA levels was found between FDRs and HCs.
SOD levels were significantly elevated in both BD patients and FDRs compared to HCs.
After adjusting for medication use, SOD differences remained significant only in FDRs.
ROC analyses indicated modest discriminative performance for IMA and SOD (AUC range: 0.63–0.66).
Clinical Implications
Further investigation is needed to explore the role of IMA and SOD in bipolar disorder.
Conclusion
The study evaluates the roles of IMA and SOD in bipolar disorder.
