Physicians’ acceptance of large language model–based clinical decision support tools in gynecologic oncology: a technology acceptance model study - Report - MDSpire

Physicians’ acceptance of large language model–based clinical decision support tools in gynecologic oncology: a technology acceptance model study

  • By

  • Jan Lennart Stalp

  • Juliane Alexandra Schneider

  • Anna Krause

  • Lena Steinkasserer

  • Jens Hachenberg

  • Agnieszka Denecke

  • Peter Hillemanns

  • Dominik Wolff

  • July 14, 2026

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Acceptance of Clinical Decision Support Tools Utilizing Large Language Models by Physicians in Gynecologic Oncology

Overview

This pilot study evaluates the acceptance of large language model-based clinical decision support systems (LLM-CDSS) among gynecologic oncologists. No significant factors were identified that influenced the willingness to use these tools.

Background

The integration of clinical decision support tools in gynecologic oncology is important due to the evolving nature of treatment guidelines and evidence. LLM-CDSS have the potential to assist clinicians by synthesizing patient-specific information with current guidelines.

Data Highlights

No significant factors influencing willingness to use LLM-CDSS were identified in the study.

Key Findings

  • 29 physicians participated in the survey assessing acceptance of LLM-CDSS.
  • Descriptive analysis showed a generally positive attitude towards LLM-CDSS.
  • Acceptance was reported to depend on transparency, evidence integration, clinical validation, and physician oversight.
  • Participants expressed concerns regarding clinical autonomy and patient trust.
  • Survey results indicated an acquiescence bias in responses.

Clinical Implications

The study discusses factors related to the acceptance of LLM-CDSS among gynecologic oncologists.

Conclusion

The pilot study reveals insights into gynecologic oncologists' acceptance of LLM-CDSS, indicating the need for further validation in larger cohorts.

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  9. Updated overall survival analysis and examination of subsequent therapy in endometrial cancer (EC) patients (pts) treated with pembrolizumab plus carboplatin/paclitaxel (CP) as compared to CP plus placebo (PBO) in the NRG-GY018 trial. | Journal of Clinical Oncology
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