Robust nasality representation learning for cleft palate-related velopharyngeal dysfunction screening in real-world settings - Report - MDSpire

Robust nasality representation learning for cleft palate-related velopharyngeal dysfunction screening in real-world settings

  • By

  • Weixin Liu

  • Bowen Qu

  • Amy Stone

  • Maria Powell

  • Shama Dufresne

  • Stephane Braun

  • Izabela Galdyn

  • Michael Golinko

  • Bradley Malin

  • Zhijun Yin

  • Matthew E. Pontell

  • July 16, 2026

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Clinical Report: Enhanced Learning of Nasality Representation for Screening VPD

Overview

This study presents a two-stage framework to enhance the robustness of machine learning models for screening velopharyngeal dysfunction (VPD) in uncontrolled environments. The proposed method demonstrates performance in both in-domain and out-of-domain settings.

Background

Velopharyngeal dysfunction (VPD) significantly impacts speech intelligibility and communication, particularly in patients with cleft palate. Traditional screening methods require specialized expertise and controlled environments, which are often unavailable in low- and middle-income countries. This study addresses the need for VPD screening tools that can operate effectively in everyday acoustic conditions.

Data Highlights

ConditionMacro-F1Accuracy
In-domain (best performance)1.0001.000
Out-of-domain (proposed method)0.6790.695
Out-of-domain (MFCC baseline)0.6120.641

Key Findings

  • The proposed method achieved ceiling performance in in-domain recordings (macro-F1 = 1.000, accuracy = 1.000).
  • In a nested 5-fold cross-validation, the best mean performance was with SVM (macro-F1 = 0.981 ± 0.022, accuracy = 0.985 ± 0.016).
  • In out-of-domain recordings, the proposed method outperformed the strongest baseline (MFCC) by +0.067 macro-F1 and +0.054 accuracy.
  • Machine learning models often degrade in performance when applied to uncontrolled environments due to domain shift.
  • Learning a nasality-focused representation can improve robustness against recording artifacts.

Clinical Implications

This study presents findings on the adaptation of machine learning models for VPD screening in real-world settings.

Conclusion

The study demonstrates that enhancing nasality representation through supervised learning can improve the performance of VPD screening tools in diverse acoustic environments.

Related Resources & Content

  1. American Cleft Palate-Craniofacial Association, 2025 -- Parameters of Care
  2. JMIR Medical Informatics, 2026 -- Natural Language Processing for Automated Classification of Cleft and Craniofacial Procedures From Operative Notes: Model Development and Feasibility Study
  3. Data-Driven Automation for Plate Design in Preoperative Management of Cleft Lip and Palate, 2023
  4. NeuroLens: Utilizing Natural Language Commands for Anatomical Identification in Surgical Education, 2025
  5. npj Digital Medicine — A device-invariant multi-modal learning framework for respiratory disease classification
  6. https://acpacares.org/wp-content/uploads/2025/02/2024-ACPA_ParametersOfCare_Final.pdf
  7. untitled
  8. Ground-truth validation of the "earbuds method" for measuring acoustic nasalance - PubMed
  9. What Technique Results in the Lowest Rate of Velopharyngeal Insufficiency in Patients With Submucous Cleft Palate? A Systematic Review and Meta-Analysis

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