The synergy of nutritional risk and iron deficiency as a predictor of mortality in older emergency department patients - Report - MDSpire
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Combined Nutritional Risk and Iron Deficiency as Indicators of 28-Day Mortality in Elderly Patients in the Emergency Department

  • By

  • Chao Zhang

  • Shijia Li

  • Ziyi Li

  • Xinhua He

  • July 21, 2026

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Clinical Report: Combined Nutritional Risk and Iron Deficiency in Elderly ED Patients

Overview

This study investigates the combined impact of nutritional risk and iron deficiency on 28-day mortality in elderly patients in the emergency department.

Background

Older adults in emergency departments often face complex health challenges, including malnutrition and iron deficiency, both of which are associated with poor clinical outcomes.

Data Highlights

Group28-Day Mortality RateAdjusted HR
G1 (mNUTRIC < 5, no ID)22.8%1.0
G4 (mNUTRIC ≥ 5, with ID)42.7%4.901

Key Findings

  • The overall 28-day mortality rate among participants was 22.8%.
  • Patients with both high nutritional risk and iron deficiency (G4) had a mortality rate of 42.7%.
  • The risk of mortality for G4 patients was 4.9 times greater than for G1 patients (adjusted HR = 4.901).
  • Hemoglobin levels were identified as a strong independent protective factor (HR = 0.976).
  • The excess mortality risk in G4 was significantly higher in patients with concurrent anemia (HR = 6.224).
  • The combination of mNUTRIC score, hemoglobin, and iron deficiency provided the best prediction of 28-day mortality (AUC = 0.779).

Clinical Implications

The findings indicate the importance of assessing both nutritional risk and iron deficiency in elderly patients in emergency settings.

Conclusion

The coexistence of high nutritional risk and iron deficiency is associated with increased mortality risk in older emergency department patients.

Related Resources & Content

  1. Clinical Research in Cardiology, 2020 -- Prevalence of Iron Deficiency in the General Population and Its Independent Association with All-Cause Mortality: Findings from the Gutenberg Health Study
  2. Intensive Care Medicine, 2017 -- Research Priorities in Nutrition and Metabolism for Intensive Care Medicine
  3. Clinical Research in Cardiology, 2020 -- Caloric Consumption During Hospitalization as a Predictor of Post-Discharge All-Cause Mortality in Elderly Patients with Heart Failure, Regardless of Nutritional Status
  4. BMC Cardiovascular Disorders, 2026 -- Iron deficiency in primary care patients with heart failure: a cross-sectional study of the heart failure in Southern Sweden (HISS) cohort
  5. The European Society for Clinical Nutrition and Metabolism (ESPEN) Guideline on Clinical Nutrition and Hydration in Geriatrics, 2026
  6. Executive summary - Guideline on haemoglobin cutoffs to define anaemia in individuals and populations, 2024
  7. [The European Society for Clinical Nutrition and Metabolism (ESPEN) Guideline on Clinical Nutrition and Hydration in Geriatrics] - PubMed
  8. Executive summary - Guideline on haemoglobin cutoffs to define anaemia in individuals and populations - NCBI Bookshelf

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