The association of Neoehrlichia mikurensis infection with polymyalgia rheumatica - Report - MDSpire

The association of Neoehrlichia mikurensis infection with polymyalgia rheumatica

  • By

  • Christine Lingblom

  • Sofia Sundvall

  • Kerstin Andersson

  • Alaitz Aranburu

  • Kristina Bengtsson Boström

  • Per Hjerpe

  • Karin Mossberg

  • Pär-Daniel Sundvall

  • Christine Wennerås

  • July 10, 2026

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Clinical Report: The Link Between Neoehrlichia mikurensis Infection and PMR

Overview

This study investigates the potential association between Neoehrlichia mikurensis infection and polymyalgia rheumatica (PMR). It highlights the clinical similarities and diagnostic challenges posed by this emerging pathogen in older adults.

Background

Neoehrlichia mikurensis is a tick-borne intracellular bacterium that can lead to neoehrlichiosis, primarily affecting older adults. Polymyalgia rheumatica is an inflammatory condition that shares symptoms with neoehrlichiosis, complicating diagnosis.

Data Highlights

No numerical or trial data presented in the source material.

Key Findings

  • Neoehrlichia mikurensis is transmitted via tick bites and primarily affects older adults.
  • Symptoms of neoehrlichiosis can mimic those of polymyalgia rheumatica, including fatigue and muscular pain.
  • The study recruited PMR patients from seven primary care centers to investigate the incidence of N. mikurensis infection.
  • Immunocompromised patients may experience more severe symptoms due to N. mikurensis infection.
  • There is a potential for misdiagnosis of N. mikurensis infection as PMR due to overlapping clinical presentations.

Clinical Implications

Healthcare professionals should consider the possibility of N. mikurensis infection in patients presenting with PMR-like symptoms, particularly in older adults.

Conclusion

The investigation into the link between N. mikurensis infection and PMR highlights the need for awareness of this emerging pathogen.

Related Resources & Content

  1. Clinical Rheumatology, 2025 -- Exploring Neoehrlichiosis in Patients with B-cell Depletion Presenting with Fever of Unknown Origin
  2. Infection, 2024 -- Septic Arthritis Due to Ureaplasma urealyticum in an Immunocompromised Individual with Hypogammaglobulinemia Following Rituximab Treatment
  3. Infection, 2024 -- Meningococcal CSF infection confirmed by PCR in the absence of pleocytosis, accompanied by elevated IL-6 and IL-8 levels
  4. Frontiers in Immunology, 2026 -- Increased optic nerve-region [18F]FDG uptake in clinically isolated polymyalgia rheumatica: an exploratory PET/CT study within the GCA-PMR spectrum
  5. Rheumatology, 2026 -- PMR guidance published December 4, 2025
  6. https://academic.oup.com/rheumatology/article/65/2/keaf646/8369094
  7. Ticks and Tick-borne Diseases 16 (2025) 102395

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