Artificial intelligence for triple-negative breast cancer from imaging to multi-omics - Report - MDSpire

Artificial intelligence for triple-negative breast cancer from imaging to multi-omics

  • By

  • Xing Peng

  • Xinyu Zhou

  • Xin Feng

  • Nimin Fang

  • Xiaoya Dong

  • Wanjing Hong

  • Tianli Li

  • Renxing Li

  • Mohammad Faidzul Nasrudin

  • June 30, 2026

  • 0 min

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Clinical Report: Utilizing Artificial Intelligence in Triple-Negative Breast Cancer

Overview

This review synthesizes the application of artificial intelligence (AI) in triple-negative breast cancer (TNBC), focusing on imaging, pathology, and multi-omics approaches.

Background

Triple-negative breast cancer (TNBC) is a challenging subtype of breast cancer characterized by its aggressive nature and lack of targeted therapies. The heterogeneity of TNBC complicates the identification of reliable biomarkers for diagnosis and treatment.

Data Highlights

This review does not contain specific numerical data or trial results.

Key Findings

  • AI has been utilized for lesion segmentation, subtype classification, and prediction of treatment response in TNBC.
  • Multimodal fusion and radiogenomic frameworks are being explored for capturing the heterogeneity of TNBC.
  • Current studies are limited by small cohorts and inconsistent endpoint definitions.
  • Robust validation and transparent reporting are essential for clinically credible AI applications in TNBC.
  • Future advancements will rely on multi-institutional data curation and privacy-preserving collaboration.

Clinical Implications

Clinicians should recognize the limitations of current studies on AI in TNBC and the importance of robust validation and integration of AI findings into clinical workflows.

Conclusion

Further research and validation are necessary to ensure the clinical utility of AI in TNBC.

Related Resources & Content

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  2. ASCO AI in Oncology, 2026 -- Transcriptomic Classifier for Predicting Neoadjuvant Immunotherapy Response in Triple-Negative Breast Cancer
  3. The ASCO Post, 2024 -- Can Artificial Intelligence Predict Treatment Response and Outcomes in Breast Cancer?
  4. Journal of Neuro-Oncology — Innovations in Artificial Intelligence for Neurosurgical Oncology: A Comprehensive Review
  5. Early-stage immuno prolongs OS in triple-negative breast cancer
  6. PARP Inhibition Shows Long-term Survival Benefits for Patients With High-risk, BRCA-positive Breast Cancer in OlympiA Trial
  7. Effectiveness of Adjuvant Capecitabine in Triple-Negative Breast Cancer Patients With Residual Disease After Neoadjuvant Treatment: A Real-World Evidence Study in Korea - PubMed
  8. FDA approves sacituzumab govitecan-hziy as monotherapy and in combination with pembrolizumab for first-line treatment of triple-negative breast cancer | FDA
  9. Outcomes in KEYNOTE-355 after chemotherapy discontinuation before pembrolizumab discontinuation and with immune-mediated adverse events | npj Breast Cancer
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  11. Germline Testing in Patients With Breast Cancer: ASCO–Society of Surgical Oncology Guideline | Journal of Clinical Oncology
  12. NCCN Guidelines® Insights: Genetic/Familial High-Risk Assessment: Breast, Ovarian, Pancreatic, and Prostate, Version 2.2026 - PubMed
  13. AI and Oncology - ASCO
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  15. CAP Updates Validation Of Immunohistochemical Assays Testing Guideline For Precise Results, Improved Patient Care - CAP
  16. Recommendations for Performance Evaluation of Machine Learning in Pathology: A Concept Paper From the College of American Pathologists - PubMed
  17. In what clinical settings are the MASAI trial results applicable? | Nature Reviews Clinical Oncology
  18. Nationwide real-world implementation of AI for cancer detection in population-based mammography screening | Nature Medicine
  19. MRI-based radiomics models for early predicting pathological response to neoadjuvant chemotherapy in triple-negative breast cancer: A systematic review and meta-analysis - PubMed
  20. Biomarker prediction of immunotherapy response in breast cancer: from single markers to multi-omics integration | npj Breast Cancer

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