Outcomes of transanal vs laparoscopic total mesorectal excision for mid and low rectal cancer under routine clinical practice conditions - Report - MDSpire

Outcomes of transanal vs laparoscopic total mesorectal excision for mid and low rectal cancer under routine clinical practice conditions

  • By

  • Chen Su

  • Junfeng Du

  • Yang Xie

  • Xiang Xu

  • Lanxin Hu

  • Xuefei Zhang

  • Yinggang Ge

  • Hongyu Zhang

  • July 8, 2026

  • 0 min

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Comparative Outcomes of Transanal and Laparoscopic Approaches to TME

Overview

This study evaluates the oncologic outcomes of transanal total mesorectal excision (TaTME) compared to laparoscopic total mesorectal excision (LapTME) in patients with mid and low rectal cancer.

Background

Total mesorectal excision (TME) is essential for curative surgery in mid and low rectal cancer, with the quality of dissection impacting recurrence and survival rates. Laparoscopic TME has gained popularity due to its minimally invasive nature, yet challenges remain in achieving optimal outcomes. TaTME was developed to enhance surgical precision and access, particularly in complex cases.

Data Highlights

This study utilized a retrospective cohort design with propensity score matching to assess 3-year oncologic outcomes, including local recurrence, distant metastasis, disease-free survival, and overall survival.

Key Findings

  • TaTME was performed using a single-team sequential approach, contrasting with LapTME's multi-port laparoscopic technique.
  • Both surgical approaches were evaluated for local recurrence and overall survival rates.
  • Early studies indicated potential advantages of TaTME, such as improved distal access and lower conversion rates.
  • Randomized trials have shown TaTME to be not inferior to LapTME in optimized settings.
  • Concerns regarding oncologic safety and heterogeneous outcomes have been raised in earlier reports.

Clinical Implications

Surgeons should consider the findings when choosing between TaTME and LapTME.

Conclusion

This study contributes to the understanding of TaTME's effectiveness compared to LapTME.

Related Resources & Content

  1. Impact of Surgical Specimen Quality on Oncological Outcomes in Open versus Laparoscopic Approaches for Mid and Low Rectal Cancer
  2. Comparative Analysis of Survival Outcomes: Transanal Total Mesorectal Excision (taTME) Versus Traditional Total Mesorectal Excision in a Propensity Score-Adjusted Retrospective Cohort Study
  3. Comparative Analysis of Robotic and Transanal Total Mesorectal Excision on Sexual, Anorectal, and Urinary Functions: A Multicenter, Prospective Observational Study
  4. Localised rectal cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up
  5. Recommendations | Transanal total mesorectal excision for rectal cancer | Guidance | NICE
  6. Comparison of Laparoscopic and Open Rectal Resection: A 1:2 Propensity Score-Matched Study on Oncological Effectiveness and Outcomes in the Short and Long Term
  7. Laparoscopic versus open surgery for rectal cancer (COLOR II): short-term outcomes of a randomised, phase 3 trial
  8. Transanal total mesorectal excision versus laparoscopic total mesorectal excision for mid and low rectal cancer (COLOR III)
  9. Localised rectal cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up - PubMed
  10. 1 Recommendations | Transanal total mesorectal excision for rectal cancer | Guidance | NICE
  11. Norwegian moratorium on transanal total mesorectal excision | BJS | Oxford Academic
  12. Outcomes of transanal total mesorectal excision compared to laparoscopic total mesorectal excision: A meta-analysis of randomized controlled trials - ScienceDirect

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