Clinical Report: Serum Creatinine Trends and Mortality in Sepsis with T2DM

Overview

This study investigates the relationship between serum creatinine trajectory patterns and 28-day mortality risk in critically ill patients with sepsis and type 2 diabetes mellitus (T2DM). It identifies three distinct serum creatinine patterns.

Background

Sepsis is a leading cause of mortality in ICU patients, particularly among those with type 2 diabetes mellitus (T2DM), who are at higher risk for acute kidney injury. Understanding the dynamics of serum creatinine changes can provide valuable prognostic information.

Data Highlights

Key Findings

• Three serum creatinine trajectory patterns identified: low-stable, moderate-increasing, and persistently high.
• Moderate-increasing and persistently high groups had significantly elevated 28-day mortality risk compared to the low-stable group.
• 28-day all-cause mortality rate was approximately 23.0% in the study population.
• Significant nonlinear association between serum creatinine levels and mortality risk was observed.
• CRRT may have a partial mediating effect on the relationship between creatinine elevation and mortality risk.

Clinical Implications

Monitoring serum creatinine trajectories in critically ill patients with sepsis and T2DM can provide important prognostic information.

Conclusion

The early trajectory of serum creatinine changes is associated with 28-day mortality in critically ill patients with sepsis and T2DM.

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