Clinical Report: Pregnancy-Related Pyogenic Granuloma of the Lower Labial Mucosa

Background

Pyogenic granuloma is a benign vascular lesion commonly found in the oral cavity, often exacerbated by hormonal changes during pregnancy. While most cases occur on the gingiva, occurrences on the labial mucosa are rare, with limited documentation in the literature.

Data Highlights

No numerical data or trial data were provided in the article.

Key Findings

• The patient was 18 weeks pregnant when a progressively enlarging mass on the lower labial mucosa was noted.
• Surgical excision was performed under local anesthesia with lidocaine without epinephrine due to recurrent bleeding and size of the mass.
• Histopathological analysis confirmed the diagnosis of lobular capillary hemangioma.
• At three-month follow-up, there were no signs of recurrence, and both maternal and fetal health remained stable.
• This case represents the earliest known gestational presentation of PG requiring surgical intervention.

Clinical Implications

The successful management of pyogenic granuloma during pregnancy through surgical excision under local anesthesia provides a reference for clinicians. It emphasizes the importance of timely intervention in cases of significant symptoms, such as recurrent bleeding.

Conclusion

This case illustrates the feasibility and safety of surgical intervention for pyogenic granuloma during pregnancy.

Related Resources & Content

1. Trever L. Siu et al., Compendium, 2023 -- Diagnosing Oral Granulomatous Lesions: A Case Report
2. The Pathologist, 2019 -- Case of the Month 8
3. Frontiers in Medicine, 2026 -- Generalized Granuloma Annulare Associated with Lung Adenocarcinoma: A Case Report
4. International Society for the Study of Vascular Anomalies -- Classification
5. PMC, 2026 -- Clinical management and surgical intervention for oral pyogenic granuloma during pregnancy: a case report
6. Nasal Lobular Capillary Hemangioma During Pregnancy: A Systematic Review
7. Oral Health Care During Pregnancy | OHRC
8. ACR Open Rheumatology — Clinical Images: Characteristics of IgG4-Related Disease in a Patient Diagnosed with Granulomatosis with Polyangiitis
9. Classification | International Society for the Study of Vascular Anomalies
10. Clinical management and surgical intervention for oral pyogenic granuloma during pregnancy: a case report - PMC
11. Nasal Lobular Capillary Hemangioma During Pregnancy: A Systematic Review
12. Oral Health Care During Pregnancy | OHRC
13. Pyogenic Granuloma - StatPearls - NCBI Bookshelf
14. Postoperative Eyelid Pyogenic Granuloma: A Systematic Review of Clinical Features, Surgical Associations, and Management - PMC
15. Topical Timolol for Pyogenic Granuloma: A Systematic Review - Bertolla - 2026 - Dermatologic Therapy - Wiley Online Library