Progressive Aortic Regurgitation and Persistent Atrial Fibrillation in a Case of Bilateral Coronary Artery Fistulas Complicated by Acute Heart Failure and Pulmonary Hypertension - Report - MDSpire

Progressive Aortic Regurgitation and Persistent Atrial Fibrillation in a Case of Bilateral Coronary Artery Fistulas Complicated by Acute Heart Failure and Pulmonary Hypertension

  • By

  • Jixia Feng

  • Xiaorong Xia

  • Jiafu Li

  • Xuefeng Wang

  • April 28, 2026

  • 0 min

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Progressive Aortic Regurgitation and Atrial Fibrillation in CAF Case

Overview

This case report details a 50-year-old male with bilateral coronary artery fistulas who developed progressive aortic regurgitation, persistent atrial fibrillation, acute heart failure, and pulmonary hypertension. Following catheter ablation and fistula closure, the patient showed significant recovery and maintained sinus rhythm during a one-year follow-up.

Background

Coronary artery fistulas (CAFs) are rare anomalies that can lead to serious complications such as arrhythmias and heart failure. The coexistence of CAFs with other cardiac conditions, such as aortic regurgitation and atrial fibrillation, complicates diagnosis and management. Understanding these relationships is crucial for developing effective treatment strategies.

Data Highlights

No numerical data available in the article.

Key Findings

  • The patient had bilateral coronary-to-pulmonary artery fistulas confirmed by imaging.
  • Progressive left atrial dilation and aortic regurgitation led to persistent atrial fibrillation.
  • Acute heart failure and pulmonary hypertension were present at diagnosis.
  • Successful catheter ablation and transcatheter closure of CAFs resulted in improved cardiac function.
  • One-year follow-up showed maintained sinus rhythm and recovery from cardiac remodeling.

Clinical Implications

This case emphasizes the need for thorough cardiac evaluations in patients with atrial fibrillation and heart failure. Individualized treatment strategies that combine pharmacological and interventional approaches are essential for optimal patient outcomes.

Conclusion

The successful management of this complex case highlights the importance of recognizing the interplay between coronary artery fistulas and other cardiac conditions. Comprehensive evaluations and tailored treatment plans are critical in improving patient outcomes.

References

  1. Pediatric Cardiology, 2011 -- Transcatheter Closure of Congenital Right Atrial Fistula Using the Amplatzer Occluder: A Case Report
  2. Clinical Research in Cardiology, 2023 -- Proposal for Comprehensive Echocardiographic Assessment of Aortic and Mitral Regurgitation in Patients with Multiple Valvular Heart Disease
  3. Pediatric Cardiology, 2022 -- A Unique Case of Congenital Aortic-Left Atrial Tunnel Accompanied by Coarctation and Anomalous Left Coronary Artery Arising from the Pulmonary Artery
  4. 2025 ACC/AHA/HRS/ISACHD/SCAI Guideline for the Management of Adults With Congenital Heart Disease - American College of Cardiology
  5. Outcomes of Transcatheter Closure of Congenital Left Circumflex Coronary Artery Fistula, 2024
  6. temple health — Advanced Diagnosis and Therapy for Paroxysmal Atrial Fibrillation and Chronic Blood Loss Anemia
  7. Advanced Diagnosis and Therapy for Paroxysmal Atrial Fibrillation and Chronic Blood Loss Anemia
  8. 2020 ACC/AHA Guideline for the Management of Patients with Valvular Heart Disease
  9. 2025 ACC/AHA/HRS/ISACHD/SCAI Guideline for the Management of Adults With Congenital Heart Disease - American College of Cardiology
  10. Outcomes of Transcatheter Closure of Congenital Left Circumflex Coronary Artery Fistula

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