Human internal exposures to alternariol and its monomethyl ether are predicted below thresholds of in vitro toxicity by physiologically based kinetic modeling - Report - MDSpire
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Human internal exposures to alternariol and its monomethyl ether are predicted below thresholds of in vitro toxicity by physiologically based kinetic modeling
Clinical Report: Physiologically Based Kinetic Modeling Predicts Human Internal Exposures
Overview
This study develops a physiologically based kinetic (PBK) model to predict human internal exposures to alternariol (AOH) and its monomethyl ether (AME) after oral intake.
Background
Emerging mycotoxins like AOH and AME pose significant food safety concerns due to their widespread occurrence in various food commodities and potential health risks. Regulatory frameworks for these toxins remain limited.
Data Highlights
No numerical data or trial data provided in the source material.
Key Findings
The PBK model predicts time-resolved tissue concentrations of AOH and AME in humans.
Chronic dietary exposure to AOH and AME may exceed toxicological concern thresholds in some populations.
AOH and AME have been shown to induce genotoxicity and oxidative stress in various in vitro studies.
Both toxins act as weak estrogen receptor agonists.
The model incorporates physiological, physicochemical, and kinetic parameters.
Clinical Implications
The findings highlight the need for ongoing monitoring of AOH and AME in food products to safeguard public health. The use of PBK modeling can facilitate more accurate risk assessments for emerging mycotoxins, potentially guiding regulatory decisions.
Conclusion
The study underscores the importance of PBK modeling in predicting human exposure to mycotoxins and the need for further research to address regulatory gaps concerning AOH and AME.
