Case Report: Persistent fifth aortic arch with coarctation and fourth aortic arch interruption causing infant heart failure – the prenatal and postnatal echocardiographic course - Report - MDSpire

Case Report: Persistent fifth aortic arch with coarctation and fourth aortic arch interruption causing infant heart failure – the prenatal and postnatal echocardiographic course

  • By

  • Xiaohong Zhang

  • Guozhen Yuan

  • Kunpeng Li

  • Yangcan Duan

  • Junli Hu

  • Dongchen Fan

  • May 22, 2026

  • 0 min

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Clinical Report: Ongoing Fifth Aortic Arch Persistence with Coarctation

Overview

This case study presents a rare instance of persistent fifth aortic arch (PFAA) with fourth aortic arch interruption leading to heart failure in an infant. The infant underwent successful surgical intervention, resulting in improved cardiac function and unobstructed aortic arch flow one year postoperatively.

Background

Persistent fifth aortic arch with fourth aortic arch interruption is a rare congenital anomaly that can lead to significant hemodynamic complications. Prenatal diagnosis is challenging due to the absence of significant abnormalities during fetal life, often resulting in missed diagnoses. Understanding this condition is crucial for timely intervention and improved outcomes in affected infants.

Data Highlights

No numerical data available in the article.

Key Findings

['The infant presented with worsening cough at 90 days of life, highlighting the late onset of symptoms.', 'Postnatal echocardiography confirmed PFAA with coarctation and fourth arch interruption.', 'Surgical intervention included resection of the coarctation segment and reconstruction of the aortic arch.', 'One year post-surgery, echocardiography showed unobstructed aortic arch flow and recovery of left ventricular function.', 'PFAA is often misidentified in prenatal ultrasounds due to subtle hemodynamic signs.']

Clinical Implications

Healthcare professionals should maintain a high index of suspicion for rare aortic arch anomalies in infants presenting with respiratory symptoms. Early recognition and surgical intervention are critical for improving outcomes in patients with PFAA and related conditions.

Conclusion

This case underscores the importance of awareness and understanding of rare congenital heart defects for timely diagnosis and management. Improved prenatal screening techniques may enhance early detection and intervention.

Related Resources & Content

  1. Pediatric Cardiology, 2020 -- Resection of Ross-Konno and Endocardial Fibroelastosis Following Hybrid Stage I Palliation in Infants: Effective Staged Rehabilitation of the Left Ventricle and Transition to Biventricular Circulation Post Fetal Diagnosis of Aortic Stenosis
  2. Pediatric Cardiology, 2022 -- A Unique Case of Congenital Aortic-Left Atrial Tunnel Accompanied by Coarctation and Anomalous Left Coronary Artery Arising from the Pulmonary Artery
  3. Pediatric Cardiology, 2024 -- Proceedings from the 2024 Fetal and Neonatal Cardiac Symposium in Chicago, IL
  4. Pediatric Cardiology, 2020 -- Prenatal Echocardiographic Measurements: Key Indicators for Postnatal Coarctation of the Aorta
  5. Icahn School of Medicine at Mount Sinai, 2023 -- Performance of Early Fetal Echocardiography: An Expert Statement from the Fetal Heart Society
  6. Milestones in paediatric cardiology: how prostaglandins revolutionised the management of CHD
  7. 2025 ACC/AHA/HRS/ISACHD/SCAI Guideline for the Management of Adults With Congenital Heart Disease
  8. Performance of Early Fetal Echocardiography: An Expert Statement from the Fetal Heart Society - Icahn School of Medicine at Mount Sinai

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