Size and location of intracranial hemorrhage in acute stroke presentations: correlation with baseline NIHSS and relevance to direct-to-angiography workflows - Report - MDSpire
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Assessment of Intracranial Hemorrhage Size and Location in Acute Stroke Cases: Its Relationship with Initial NIHSS Scores and Implications for Direct-to-Angiography Protocols

  • By

  • Anh Nguyen

  • Mira Katan

  • Raphael Guzman

  • Jehuda Soleman

  • Christian Nickel

  • Marios-Nikos Psychogios

  • Alex Brehm

  • September 8, 2026

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Clinical Report: Assessment of Intracranial Hemorrhage Size and Location

Overview

This study characterizes intracranial hemorrhage (ICH) in acute stroke cases, focusing on the relationship between hemorrhage size, location, and initial NIHSS scores.

Background

Intracranial hemorrhage is a significant cause of morbidity and mortality in stroke patients. Accurate assessment of ICH is crucial for timely and appropriate treatment, particularly in the context of direct-to-angiography protocols that aim to expedite care.

Data Highlights

Hemorrhage TypePercentage
Intraparenchymal89%
Subarachnoid7%
Intraventricular3%
Subdural<1%

Key Findings

  • Intraparenchymal hemorrhage accounted for 89% of cases in the study cohort.
  • The median volume of hemorrhage was 18 mL, with a significant correlation to NIHSS scores (Spearman ρ = 0.56, p < 0.001).
  • Patients with NIHSS ≥7 had larger hemorrhages (median 38 mL) compared to those with NIHSS <7 (median 6 mL).
  • Lobar hemorrhages exhibited the greatest volumes, while infratentorial hemorrhages, particularly in the brainstem, caused severe deficits despite smaller volumes.
  • Only 2.8% of patients with NIHSS ≥7 had isolated infratentorial hemorrhage.

Clinical Implications

The findings highlight the importance of considering both volume and location when assessing ICH in acute stroke patients.

Conclusion

This study examines the relationship between ICH characteristics and stroke severity.

Related Resources & Content

  1. AHA/ASA, AHA/ASA Early Management of Acute Ischemic Stroke 2026 -- Guideline Position
  2. ScienceDirect, Direct transfer to angiosuite vs conventional workup for stroke: A systematic review and meta-analysis -- 2025
  3. Frontiers, Size and location of intracranial hemorrhage in acute stroke presentations: correlation with baseline NIHSS and relevance to direct-to-angiography workflows -- 2026
  4. European Radiology — Predictive Features of Non-contrast CT for Growth of Intraventricular Hemorrhage
  5. European Radiology — Evaluation of Assessment Tools for Aneurysmal Subarachnoid Hemorrhage: A Retrospective Cohort Analysis
  6. Characteristics of Intracranial Lesions in Moderate to Severe Traumatic Brain Injury: Association with Neurointensive Care Factors and Patient Outcomes
  7. European Radiology — Forecasting Lesion Recovery in Acute Cerebral Ischemia Using Apparent Diffusion Coefficient Thresholds from Diffusion-Weighted MRI
  8. AHA GUIDELINES Bundle (free trial) - AHA/ASA Early Management of Acute Ischemic Stroke 2026
  9. Direct transfer to angiosuite vs conventional workup for stroke: A systematic review and meta-analysis - ScienceDirect
  10. Frontiers | Size and location of intracranial hemorrhage in acute stroke presentations: correlation with baseline NIHSS and relevance to direct-to-angiography workflows

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