Clinical Report: The Association of Hemoglobin Glycation Index with Short-Term Mortality in Sepsis
Overview
This study investigates the relationship between hemoglobin glycation index (HGI) and short-term mortality in critically ill patients with sepsis. Higher HGI levels were associated with lower 28-day mortality rates.
Background
Sepsis is a significant cause of mortality, characterized by a dysregulated response to infection leading to systemic inflammation and multi-organ failure. Accurate risk stratification is essential for improving clinical outcomes, and glycemic dysregulation plays a critical role in sepsis prognosis. The hemoglobin glycation index (HGI) may provide insights beyond traditional glycemic measures, capturing interindividual variability in glycation.
Data Highlights
Mortality Rate
28-Day
60-Day
90-Day
Rate (%)
23.25
27.69
30.00
Key Findings
Non-survivors had significantly lower HGI levels than survivors (p < 0.001).
Patients in the highest HGI quartile (Q4) had a lower risk of 28-day mortality (HR 0.70, 95% CI 0.52–0.94; p = 0.018).
A similar trend was observed for 60-day mortality (HR 0.76, 95% CI 0.58–1.00; p = 0.050).
Higher HGI was associated with reduced 28-day mortality in an external validation cohort.
HGI may capture interindividual differences in glycation tendency and metabolic instability.
Clinical Implications
Further prospective studies are necessary to validate these results.
Conclusion
Higher HGI is associated with lower short-term mortality in sepsis patients, particularly at 28 days.
