Dose–response relationship of exercise interventions on sleep quality in patients with depression: a systematic review and meta-analysis - Report - MDSpire

Dose–response relationship of exercise interventions on sleep quality in patients with depression: a systematic review and meta-analysis

  • By

  • Ziqi Gao

  • Sujie Mao

  • Yaxin Wang

  • Huimin Yang

  • Chang Liu

  • Jiahe Wu

  • Jianxin Kang

  • June 30, 2026

  • 0 min

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Clinical Report: Impact of Exercise Interventions on Sleep Quality in Depressed Patients

Overview

This systematic review and meta-analysis evaluated the effects of exercise interventions on sleep quality in depressed patients, finding significant improvements. The analysis included 19 randomized controlled trials with 1,457 participants, revealing a dose-response relationship favoring specific exercise parameters.

Background

Depression is a prevalent psychiatric disorder that significantly impacts quality of life, with sleep disturbances affecting over 80% of individuals with depression. Exercise interventions have emerged as a promising non-pharmacological approach to improve sleep quality in this population.

Data Highlights

MeasureEffect Size (SMD)95% CI
Overall Exercise Intervention-0.37-0.48 to -0.27
Mind-Body Exercise-0.49-0.63 to -0.35
Duration 9-12 weeks-0.49-0.74 to -0.24
Fewer than 2 sessions/week-0.47-0.65 to -0.29
Sessions >90 minutes-0.42-0.66 to -0.18

Key Findings

  • Exercise interventions significantly improved sleep quality in depressed patients (SMD = -0.37).
  • Optimal exercise dose for sleep quality improvement was around 312.75 MET·min/week (Hedges’ g = -0.51).
  • Mind-body exercises showed a significant effect on sleep quality (SMD = -0.49).
  • Exercise durations of 9-12 weeks were associated with favorable outcomes (SMD = -0.49).
  • Fewer than two sessions per week also yielded positive effects (SMD = -0.47).
  • Sessions longer than 90 minutes contributed to improved sleep quality (SMD = -0.42).

Clinical Implications

Healthcare professionals may consider incorporating exercise interventions as part of treatment plans for patients with depression to enhance sleep quality. Individualized exercise prescriptions based on the identified dose-response relationships may optimize therapeutic outcomes.

Conclusion

Further research is needed to confirm these findings.

Related Resources & Content

  1. Khazaie et al., Frontiers in Medicine, 2026 -- Exercise Intervention on Sleep Quality in Alzheimer's Disease: A Systematic Review and Meta-Analysis
  2. Frontiers in Psychiatry, 2026 -- Physical Activity Interventions on Health-Related Quality of Life (HR-QoL) in Major Depressive Disorder (MDD): A Systematic Review and Meta-Analysis of Randomized Controlled Trials
  3. Frontiers in Psychiatry, 2026 -- Comparative effects of structured exercise protocols on depression and anxiety symptoms: a network meta-analysis
  4. VA/DoD Clinical Practice Guideline for the Management of Major Depressive Disorder (MDD), 2022
  5. BMC Pregnancy and Childbirth — Effects of different types of exercise interventions on perinatal depression, anxiety, and quality of life: a systematic review and meta-analysis
  6. VA/DoD_Clinical_Practice_Guideline_for_the_Management_of_Major_Depressive_Disorder_(MDD)
  7. Effects of Aerobic Exercises at Different Intensities on Sleep Quality in Individuals with Depression: A Systematic Review and Meta-Analysis - PMC
  8. https://trends.org.br/article/10.47626/2237-6089-2025-1120/pdf/trends-0-AheadOfPrint-68c164e2a953957d8e77e725.pdf

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