Intraoperative radiotherapy after resection of newly diagnosed brain metastases in adult patients - results of a prospective phase II trial (INTRAMET) - Report - MDSpire

Intraoperative radiotherapy after resection of newly diagnosed brain metastases in adult patients - results of a prospective phase II trial (INTRAMET)

  • By

  • Stefanie Brehmer

  • Gustavo R. Sarria

  • Sara Würfel

  • Ardita Sulejmani

  • Frank Schneider

  • Sven Clausen

  • Yasser Abo-Madyan

  • Arne M. Ruder

  • Elena Sperk

  • Nima Etminan

  • Frank A. Giordano

  • May 28, 2026

  • 0 min

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Clinical Report: Prospective Phase II Trial Results of Intraoperative Radiotherapy Following Resection of Newly Diagnosed Brain Metastases in Adult Patients (INTRAMET)

Overview

{'local_control_rates': 'Specify the exact rates observed in the trial.', 'toxicity_profiles': 'Detail the types of toxicity reported.'}

Background

{'recurrence_rates': 'Include specific statistics on local recurrence rates without adjuvant therapy.'}

Data Highlights

{'remove_placeholder': 'Replace with actual data if available.'}

Key Findings

{'local_control_rates': 'Add specific rates and toxicity levels.'}

Clinical Implications

{'limitations': 'Discuss any limitations or considerations for IORT.'}

Conclusion

{'future_research': 'Identify specific areas for further investigation.'}

Related Resources & Content

  1. Author(s)/Org, Source, Year -- Title
  2. Journal of Neuro-Oncology — Evaluation of Intra-cavitary Radiotherapy Techniques for Resected Brain Metastases: An In-depth Review with Individual Patient Data Meta-analysis of Intraoperative Radiotherapy (IORT) and Brachytherapy (IBT)
  3. Journal of Neuro-Oncology — Evaluating Intraoperative Radiotherapy versus Hypofractionated Stereotactic Radiotherapy Following Brain Metastasis Surgery: Effects on Cancer Outcomes and Radionecrosis
  4. Journal of Neuro-Oncology — Update on Oncological Outcomes Following Intraoperative Radiotherapy After Neurosurgical Resection of Brain Metastases: A Single-Center Cohort Analysis of 117 Cases
  5. Journal of Neuro-Oncology — Evaluation of Intraoperative Radiotherapy Outcomes for Brain Metastases: Findings from a Prospective Observational Study with Matched-Pair Comparison
  6. Postoperative stereotactic radiosurgery compared with whole brain radiotherapy for resected metastatic brain disease (NCCTG N107C/CEC·3): a multicentre, randomised, controlled, phase 3 trial
  7. Intraoperative radiotherapy after resection of newly diagnosed brain metastases in adult patients - results of a prospective phase II trial (INTRAMET) - PMC
  8. Preoperative versus postoperative stereotactic radiosurgery for brain metastases: a systematic review and meta-analysis of comparative studies - PubMed

Original Source(s)

Intraoperative radiotherapy after resection of newly diagnosed brain metastases in adult patients - results of a prospective phase II trial (INTRAMET)

  • by Stefanie Brehmer, Gustavo R. Sarria, Sara Würfel, Ardita Sulejmani, Frank Schneider, Sven Clausen, Yasser Abo-Madyan, Arne M. Ruder, Elena Sperk, Nima Etminan, Frank A. Giordano

  • May 28, 2026

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