Intraoperative radiotherapy after resection of newly diagnosed brain metastases in adult patients - results of a prospective phase II trial (INTRAMET) - Report - MDSpire
Coming Soon: Introducing MDSpire News. Learn more
Conexiant’s news site is now MDSpire News. Learn more

Prospective Phase II Trial Results of Intraoperative Radiotherapy Following Resection of Newly Diagnosed Brain Metastases in Adult Patients (INTRAMET)

  • By

  • Stefanie Brehmer

  • Gustavo R. Sarria

  • Sara Würfel

  • Ardita Sulejmani

  • Frank Schneider

  • Sven Clausen

  • Yasser Abo-Madyan

  • Arne M. Ruder

  • Elena Sperk

  • Nima Etminan

  • Frank A. Giordano

  • May 28, 2026

Share

Clinical Report: Prospective Phase II Trial Results of Intraoperative Radiotherapy Following Resection of Newly Diagnosed Brain Metastases in Adult Patients (INTRAMET)

Overview

{'local_control_rates': 'Specify the exact rates observed in the trial.', 'toxicity_profiles': 'Detail the types of toxicity reported.'}

Background

{'recurrence_rates': 'Include specific statistics on local recurrence rates without adjuvant therapy.'}

Data Highlights

{'remove_placeholder': 'Replace with actual data if available.'}

Key Findings

{'local_control_rates': 'Add specific rates and toxicity levels.'}

Clinical Implications

{'limitations': 'Discuss any limitations or considerations for IORT.'}

Conclusion

{'future_research': 'Identify specific areas for further investigation.'}

Related Resources & Content

  1. Author(s)/Org, Source, Year -- Title
  2. Journal of Neuro-Oncology — Evaluation of Intra-cavitary Radiotherapy Techniques for Resected Brain Metastases: An In-depth Review with Individual Patient Data Meta-analysis of Intraoperative Radiotherapy (IORT) and Brachytherapy (IBT)
  3. Journal of Neuro-Oncology — Evaluating Intraoperative Radiotherapy versus Hypofractionated Stereotactic Radiotherapy Following Brain Metastasis Surgery: Effects on Cancer Outcomes and Radionecrosis
  4. Journal of Neuro-Oncology — Update on Oncological Outcomes Following Intraoperative Radiotherapy After Neurosurgical Resection of Brain Metastases: A Single-Center Cohort Analysis of 117 Cases
  5. Journal of Neuro-Oncology — Evaluation of Intraoperative Radiotherapy Outcomes for Brain Metastases: Findings from a Prospective Observational Study with Matched-Pair Comparison
  6. Postoperative stereotactic radiosurgery compared with whole brain radiotherapy for resected metastatic brain disease (NCCTG N107C/CEC·3): a multicentre, randomised, controlled, phase 3 trial
  7. Intraoperative radiotherapy after resection of newly diagnosed brain metastases in adult patients - results of a prospective phase II trial (INTRAMET) - PMC
  8. Preoperative versus postoperative stereotactic radiosurgery for brain metastases: a systematic review and meta-analysis of comparative studies - PubMed

Original Source(s)

Intraoperative radiotherapy after resection of newly diagnosed brain metastases in adult patients - results of a prospective phase II trial (INTRAMET)

  • by Stefanie Brehmer, Gustavo R. Sarria, Sara Würfel, Ardita Sulejmani, Frank Schneider, Sven Clausen, Yasser Abo-Madyan, Arne M. Ruder, Elena Sperk, Nima Etminan, Frank A. Giordano

  • May 28, 2026

Related Content

Author Correction: Activating mutations in CSF1R and additional receptor tyrosine kinases in histiocytic neoplasms

Fellowship-Trained Neuro-Oncologist Nishika Karbhari, M.D., Joins Baptist Health Herbert Wertheim Cancer Institute

Fellowship-trained neuro-oncologist Nishika Karbhari, M.D., has joined Baptist Health Herbert Wertheim Cancer Institute.

  • by

  • September 3, 2026

  • 2 min
AI-Designed Binder Improves CAR T Cell Activity in Mice

Researchers screened 1,758 de novo protein binders and identified design features that influence CAR T cell activation, specificity, and tumor control

  • September 15, 2026

  • 3 min