Radiomics-Based AI for the Diagnosis and Prognosis of Vessels Encapsulating Tumor Clusters in Hepatocellular Carcinoma: Systematic Review and Meta-Analysis - Report - MDSpire

Radiomics-Based AI for the Diagnosis and Prognosis of Vessels Encapsulating Tumor Clusters in Hepatocellular Carcinoma: Systematic Review and Meta-Analysis

  • By

  • Xuefeng Hua

  • Rongdang Fu

  • Ziwei Yin

  • July 2, 2026

  • 0 min

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Clinical Report: AI-Driven Radiomics for Assessing Diagnosis and Prognosis of Tumor Cluster-Encapsulating Vessels in Hepatocellular Carcinoma

Overview

This comprehensive review and meta-analysis evaluates the efficacy of AI-driven radiomics in predicting the presence of vessels encapsulating tumor clusters (VETCs) in hepatocellular carcinoma (HCC).

Background

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality, with a high recurrence rate and limited treatment options. The identification of VETCs serves as a critical prognostic factor, influencing patient outcomes. Traditional diagnostic methods are invasive and limited.

Data Highlights

No numerical data available in the provided material.

Key Findings

  • VETC positivity is an independent poor prognostic factor in HCC, linked to higher recurrence rates.
  • AI-based radiomics can predict VETC status.
  • Existing studies show variability in AI model performance.
  • Traditional imaging methods have limitations due to tumor heterogeneity and subjective interpretation.
  • This review addresses gaps in previous studies by integrating various imaging modalities and methodological assessments.

Clinical Implications

The integration of AI-driven radiomics in clinical practice may enhance preoperative assessments for HCC.

Conclusion

AI-driven radiomics represents an advancement in the noninvasive assessment of VETCs in HCC.

Related Resources & Content

  1. Frontiers in Oncology, 2026 -- Pre-treatment CEMRI habitat radiomics and deep learning for noninvasive prediction of the VETC pattern in hepatocellular carcinoma: an exploratory radiogenomic analysis
  2. Frontiers in Oncology, 2026 -- CT-based habitat imaging integrated with radiomics and clinicopathology for noninvasive prediction of microvascular invasion in hepatocellular carcinoma
  3. Frontiers in Medicine, 2026 -- Prediction of the efficacy after the first transarterial chemoembolization in hepatocellular carcinoma using CT radiomics combined with inflammatory composite indicators
  4. Critical Update: AASLD Practice Guidance on prevention, diagnosis, and treatment of hepatocellular carcinoma - PubMed
  5. Frontiers in Oncology — Habitat and peritumoral CT radiomics accurately predict early treatment response to hepatic arterial infusion chemotherapy combined with tyrosine kinase inhibitors and programmed death‑1 inhibitors in unresectable hepatocellular carcinoma
  6. Effectiveness of Machine Learning in Detecting Vessels Encapsulating Tumor Clusters in Hepatocellular Carcinoma: Systematic Review and Meta-Analysis
  7. Updated data from IMbrave050: Adjuvant atezolizumab plus bevacizumab for high-risk hepatocellular carcinoma
  8. Critical Update: AASLD Practice Guidance on prevention, diagnosis, and treatment of hepatocellular carcinoma - PubMed

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