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CKM staging faces an early vascular test
Investigators examined Life’s Essential 8 scores and carotid ultrasonography measures across cardiovascular-kidney-metabolic stages in 1,283 young adults.
Clinical Report: CKM Staging Faces an Early Vascular Test
Overview
A cross-sectional study involving 1,283 young adults found that more advanced stages of cardiovascular-kidney-metabolic syndrome (CKM) were linked to lower cardiovascular health scores and increased early carotid arterial injury.
Background
Understanding the relationship between cardiovascular health and CKM syndrome is crucial, especially as these conditions can significantly impact long-term health outcomes.
Data Highlights
CKM Stage
Percentage of Participants
Mean Life’s Essential 8 Score
Mean-Maximum Carotid Intima-Medial Thickness (mm)
Stage 0
21%
78
-
Stage 1
40%
70
0.014 higher than Stage 0
Stage 2
36%
64
0.020 higher than Stage 0
Stage 3
3%
64
0.100 higher than Stage 0
Key Findings
Participants were classified into CKM stages with 21% at stage 0, 40% at stage 1, 36% at stage 2, and 3% at stage 3.
Adjusted mean Life’s Essential 8 scores decreased from 78 in stage 0 to 64 in stages 2 and 3.
More advanced CKM stages correlated with higher mean-maximum carotid intima-medial thickness.
Mean-maximum carotid intima-medial thickness was 0.100 mm higher in stage 3 compared to stage 0.
Scores for health-behavior components did not differ statistically across CKM stages, possibly due to limitations in self-reported data.
The study highlights the association of CKM stages with early markers of carotid arterial injury in young adults.
Clinical Implications
The findings indicate that young adults with advanced CKM stages may be at increased risk for cardiovascular issues.
Conclusion
This study highlights the association of CKM staging with early cardiovascular risk factors among young adults.
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