Concurrent Lobular Endocervical Glandular Hyperplasia and SCT in PJS

Overview

This case study presents a 25-year-old woman with Peutz–Jeghers syndrome (PJS) who exhibited concurrent lobular endocervical glandular hyperplasia (LEGH) and a sex-cord tumor with annular tubules (SCTATs). The findings underscore the importance of regular gynecological surveillance in PJS patients due to their increased risk of gynecological tumors.

Background

Peutz–Jeghers syndrome (PJS) is an autosomal dominant disorder that significantly increases the risk of various malignancies, particularly gynecological tumors. The association of LEGH and SCTATs in a single patient highlights the diverse spectrum of gynecological pathology linked to PJS. Understanding these associations is crucial for early detection and management of potential malignancies in affected individuals.

Data Highlights

No numerical data or trial data available in the article.

Key Findings

Clinical Implications

Healthcare providers should maintain a high index of suspicion for gynecological tumors in patients with PJS, particularly during routine examinations. Early detection through regular surveillance can lead to timely intervention and improved outcomes for affected patients.

Conclusion

This case illustrates the rare co-occurrence of LEGH and SCTATs in a patient with PJS, emphasizing the need for vigilant gynecological monitoring in this population.

References

1. Peutz-Jeghers Syndrome, NCBI, 2023 -- Overview and Management
2. Acta Neuropathologica — Primary Papillary Epithelial Tumor of the Sella with an EZH2 Y646F Mutation
3. The ASCO Post — Rates of Occult Gastric Carcinoma in Patients With Hereditary Lobular Breast Cancer Due to CDH1 Genetic Variants
4. Gastric Cancer — Early-onset diffuse gastric carcinoma linked to a novel large genomic deletion in the CDH1 gene
5. Gastric Cancer — Case Study of Multiple Foveolar-Type Gastric Adenomas in a Patient Without Helicobacter pylori Infection Following Prolonged Proton Pump Inhibitor Therapy
6. MRI grading for informed clinical decision-making in Peutz–Jeghers syndrome patients with cervical lesions
7. Peutz-Jeghers Syndrome
8. Effects of different surgical extents on prognosis of patients with malignant ovarian sex cord-stromal tumors: a retrospective cohort study | Scientific Reports