Clinical Report: Global Prevalence and Associated Risk Factors of Hyperuricemia and Gout

Overview

This systematic review and meta-analysis estimates the global prevalence of hyperuricemia (HUA) and gout in patients with type 2 diabetes mellitus (T2DM), finding a pooled prevalence of 22.0% for HUA and 6.0% for gout. Key risk factors identified include impaired renal function, obesity, dyslipidemia, hypertension, metabolic syndrome, and alcohol consumption.

Background

Type 2 diabetes mellitus (T2DM) is a prevalent metabolic disease that significantly impacts global health. Hyperuricemia and gout are common comorbidities in T2DM patients. Understanding the prevalence and risk factors for these conditions is crucial.

Data Highlights

Key Findings

• The pooled prevalence of hyperuricemia in T2DM patients is 22.0%.
• The pooled prevalence of gout in T2DM patients is 6.0%.
• Geographic region significantly affects the prevalence of hyperuricemia, with the highest rates in Africa and North America.
• Risk factors for hyperuricemia include impaired renal function, obesity, dyslipidemia, hypertension, metabolic syndrome, and alcohol consumption.
• Male sex is a significant risk factor for gout.
• Elevated HbA1c is inversely associated with hyperuricemia.

Clinical Implications

Routine serum uric acid monitoring and early screening for high-risk individuals should be integrated into the clinical management of T2DM. Identifying and addressing risk factors can help mitigate the complications associated with hyperuricemia and gout.

Conclusion

The findings indicate the prevalence of hyperuricemia and gout in T2DM patients.

Related Resources & Content

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2. BMC Endocrine Disorders — The association between the triglyceride-glucose index and serum uric acid: a systematic review and meta-analysis
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8. Frontiers | Prevalence and risk factors of hyperuricemia and gout in patients with type 2 diabetes mellitus: a systematic review and meta-analysis