The effects of combined endurance and resistance exercise training in heart failure: a meta-analysis - Report - MDSpire

The effects of combined endurance and resistance exercise training in heart failure: a meta-analysis

  • By

  • Shun Hu

  • Yue Xu

  • June 23, 2026

  • 0 min

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Clinical Report: Impact of Integrated Endurance and Resistance Training on Heart Failure

Overview

This meta-analytical review evaluates the efficacy of combined endurance and resistance training in patients with heart failure, demonstrating significant improvements in peak oxygen consumption and quality of life.

Background

Chronic heart failure (CHF) is a prevalent condition with significant morbidity and mortality, affecting millions globally. Traditional pharmacological treatments can lead to adverse effects. Exercise rehabilitation has emerged as a critical component of heart failure management, with combined endurance and resistance training showing promise in enhancing patient outcomes.

Data Highlights

OutcomeMean Difference (MD)95% Confidence Interval (CI)P-value
Peak Oxygen Consumption4.361.68–7.040.001
Quality of Life-9.32-16.92 to -1.710.02
Six-Minute Walk Test53.7638.81–68.70<0.0001

Key Findings

  • Combined endurance and resistance training significantly improved peak oxygen consumption in heart failure patients.
  • Quality of life metrics showed notable enhancement in the intervention group compared to controls.
  • Performance on the six-minute walk test was significantly better in the intervention group.
  • No significant differences were found in sleep parameters or depression levels between groups.
  • Findings were stable and reliable according to sensitivity analysis.

Clinical Implications

Clinicians should consider this exercise model as part of a comprehensive rehabilitation strategy for heart failure patients.

Conclusion

Combined endurance and resistance exercise training is beneficial for improving clinical outcomes in heart failure patients.

Related Resources & Content

  1. European Journal of Preventive Cardiology, 2024 -- Comparison of exercise training modalities and change in peak oxygen consumption in heart failure with preserved ejection fraction: a secondary analysis of the OptimEx-Clin trial
  2. Frontiers in Cardiovascular Medicine, 2024 -- Exercise modalities and dose-response for LVEF Improvement in heart failure patients: a systematic review and network meta-analysis
  3. 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines - PubMed
  4. European Journal of Preventive Cardiology — Exerkines in heart failure: from molecular insights to clinical translation
  5. Frontiers in Cardiovascular Medicine — The impact of cardiac rehabilitation on rehospitalization and mortality rates in heart failure with preserved ejection fraction
  6. 2021 ESC Heart Failure guideline
  7. Latest Articles | Circulation
  8. 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines - PubMed
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  10. Effects of exercise based cardiac rehabilitation delivery modes on chronic heart failure: a systematic review and network meta-analysis | Scientific Reports
  11. Impact of exercise training on exercise tolerance, cardiac function and quality of life in individuals with heart failure and preserved ejection fraction: a systematic review and meta-analysis | BMC Cardiovascular Disorders | Springer Nature Link
  12. Frontiers | Exercise modalities and dose-response for LVEF Improvement in heart failure patients: a systematic review and network meta-analysis

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