The association of anxiety, depression, sleep quality and intradialytic hypotension in hemodialysis patients: a cross-sectional study - Report - MDSpire

The association of anxiety, depression, sleep quality and intradialytic hypotension in hemodialysis patients: a cross-sectional study

  • By

  • Xiaomei Jiang

  • Panpan Chen

  • Siyan Deng

  • Yujuan Yang

  • Yixiu Liu

  • Shuixiang Wu

  • Qinjuan Xu

  • Huagang Hu

  • Xiaowen Zhu

  • June 5, 2026

  • 0 min

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Clinical Report: Exploring the Relationship Between Anxiety, Depression, Sleep Quality, and Intradialytic Hypotension in Patients Undergoing Hemodialysis

Overview

This study investigates the prevalence of intradialytic hypotension (IDH), anxiety, depression, and sleep quality in patients undergoing maintenance hemodialysis (MHD). It finds that frequent IDH is significantly associated with higher levels of anxiety, depression, and poor sleep quality, emphasizing the need for integrated monitoring in MHD care.

Background

Patients on maintenance hemodialysis often experience high rates of psychological distress and sleep disturbances, which can adversely affect their overall health and treatment outcomes. Intradialytic hypotension is a common complication that may exacerbate these issues, yet its relationship with psychological and sleep-related symptoms has not been thoroughly explored. Understanding these associations is crucial for improving patient care and outcomes in this vulnerable population.

Data Highlights

MeasureFindings
IDH Incidence11.7%
Frequent IDH (≥4 episodes)26.3%
Anxiety Prevalence30.4%
Depression Prevalence44.3%
Poor Sleep Quality Prevalence39.9%

Key Findings

  • 11.7% of dialysis sessions were associated with intradialytic hypotension (IDH).
  • 26.3% of patients experienced frequent IDH (≥4 episodes).
  • Anxiety was present in 30.4% of the study population.
  • 44.3% of patients reported symptoms of depression.
  • 39.9% of patients experienced poor sleep quality.
  • Frequent IDH correlated significantly with higher anxiety, depression, and poor sleep quality scores (P< 0.05).

Clinical Implications

The findings suggest that healthcare providers should routinely assess psychological and sleep-related symptoms in patients undergoing hemodialysis, particularly those experiencing frequent IDH. Integrating hemodynamic monitoring with mental health and sleep assessments may enhance patient care and improve overall treatment outcomes.

Conclusion

Frequent intradialytic hypotension is linked to increased anxiety, depression, and poor sleep quality in maintenance hemodialysis patients. Addressing these interconnected issues is essential for optimizing patient management and improving quality of life.

Related Resources & Content

  1. BMC Psychiatry (Springer), 2025 -- Sarcopenia and dynapenia are associated with depression rather than anxiety in Chinese hemodialysis patients
  2. Frontiers in Psychiatry, 2026 -- Psychological distress among dialysis patients during the COVID-19 Omicron pandemic: risk and protective factors across hemodialysis and peritoneal dialysis
  3. Clinical Rheumatology, 2020 -- An Examination of Sleep Patterns and Depression Among Individuals with Rheumatoid Arthritis: A Cross-Sectional Analysis
  4. BMC Psychiatry (Springer), 2025 -- Tele-based continuous care and treatment compliance in dialysis patients with and without depression: the serial mediating effect of nurse-patient relationship and health belief
  5. Association of Mortality Risk with Various Definitions of Intradialytic Hypotension - PMC
  6. Clinical Outcomes of Patients undergoing Hemodialysis with Cool versus Standard Dialysate: A Systematic Review and Meta-Analysis | American Journal of Nephrology | Karger Publishers
  7. Comparison of Depression in Hemodialysis, Peritoneal Dialysis, and Kidney Transplant Patients: A Systematic Review with Meta-Analysis - PMC
  8. Association of Mortality Risk with Various Definitions of Intradialytic Hypotension - PMC
  9. Clinical Outcomes of Patients undergoing Hemodialysis with Cool versus Standard Dialysate: A Systematic Review and Meta-Analysis | American Journal of Nephrology | Karger Publishers
  10. Comparison of Depression in Hemodialysis, Peritoneal Dialysis, and Kidney Transplant Patients: A Systematic Review with Meta-Analysis - PMC

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