Granulomatosis with polyangiitis initially presenting as secretory otitis media: a case report - Report - MDSpire

Granulomatosis with polyangiitis initially presenting as secretory otitis media: a case report

  • By

  • Zhang, Zihan

  • CHEN, YIXI

  • Zeng, Yinping

  • Tang, Zhendong

  • Gu, Jiawei

  • Ma, Wenbo

  • Duan, Tingting

  • Zhou, Xuejun

  • June 8, 2026

  • 0 min

Share

Clinical Report: Granulomatosis with Polyangiitis Manifesting as Secretory Otitis Media

Overview

This report details a case of granulomatosis with polyangiitis (GPA) presenting as secretory otitis media in a 50-year-old woman.

Background

Granulomatosis with polyangiitis (GPA) is a rare systemic necrotizing vasculitis that can lead to morbidity if not diagnosed early. Otolaryngological manifestations, such as otitis media, can precede systemic symptoms, complicating timely diagnosis and treatment.

Data Highlights

No numerical or trial data available in the article.

Key Findings

  • The patient initially presented with secretory otitis media, misdiagnosed as infectious otitis media.
  • GPA can manifest with otological symptoms, which may lead to delayed diagnosis.
  • Otolaryngological manifestations occur in up to 73% of GPA patients.

Clinical Implications

Healthcare professionals, particularly otolaryngologists, should be aware of GPA in patients with refractory otological symptoms.

Conclusion

This case highlights the need for awareness of atypical presentations of GPA, such as secretory otitis media.

Related Resources & Content

  1. Author(s)/Org, Source, Year -- Title
  2. Author(s)/Org, Source, Year -- Title
  3. Author(s)/Org, Source, Year -- Title
  4. 2022 American College of Rheumatology/European Alliance of Associations for Rheumatology Classification Criteria for Granulomatosis With Polyangiitis
  5. Diagnosis and management of facial nerve palsy secondary to granulomatosis with polyangiitis – A systematic review
  6. Otitis Media with ANCA-associated Vasculitis: A New Concept and the Associated Criteria
  7. Clinical Rheumatology — A Rheumatologist's Insights on Benign Subglottic Stenosis: A Comprehensive Review
  8. 2025 British Society for Rheumatology management recommendations for ANCA-associated vasculitis
  9. KDIGO 2024 Guideline for ANCA-Associated Vasculitis
  10. 2022 American College of Rheumatology/European Alliance of Associations for Rheumatology Classification Criteria for Granulomatosis With Polyangiitis
  11. Diagnosis and management of facial nerve palsy secondary to granulomatosis with polyangiitis – A systematic review - ScienceDirect
  12. Otitis Media with ANCA-associated Vasculitis: A New Concept and the Associated Criteria - PMC
  13. KDOQI Provides U.S. Clinical Perspective on KDIGO 2024 Guideline for ANCA-Associated Vasculitis | National Kidney Foundation
  14. Rituximab versus cyclophosphamide for ANCA-associated vasculitis - PubMed
  15. Plasma Exchange and Glucocorticoids in Severe ANCA-Associated Vasculitis | New England Journal of Medicine
  16. Avacopan for the Treatment of ANCA-Associated Vasculitis | New England Journal of Medicine

Original Source(s)

Related Content