Linking the TyG Indicator—TyHGB with Prediabetes and Diabetes Risk

Overview

This longitudinal study identifies the triglyceride-high density lipoprotein cholesterol-glucose body index (TyHGB) in relation to prediabetes and diabetes in middle-aged and elderly postmenopausal women. The findings indicate a nonlinear dose-response relationship between TyHGB levels and diabetes risk.

Background

Diabetes mellitus is a growing global health concern, with increasing prevalence particularly among postmenopausal women. Dyslipidemia, characterized by abnormal lipid profiles, is a known risk factor for diabetes, and menopause exacerbates these metabolic changes.

Data Highlights

Key Findings

• TyHGB is associated with the risk of developing both prediabetes and diabetes.
• A nonlinear dose-response relationship exists, with prediabetes risk increasing steeply below an inflection point of 8.52.
• Diabetes risk remains stable below a TyHGB value of 6.47 and increases sharply thereafter.
• The association between TyHGB and diabetes risk is consistent across various subgroups including age and existing health conditions.
• ROC curve analysis indicates TyHGB's predictive value for diabetes risk in this population.

Clinical Implications

The TyHGB index can be utilized as a tool for assessing diabetes risk in middle-aged and elderly postmenopausal women.

Conclusion

The TyHGB index serves as a risk factor for prediabetes and diabetes.

Related Resources & Content

1. Xu et al., Frontiers in Endocrinology, 2026 -- Non-linear relationship between triglyceride glucose-body mass index and risk of diabetes in adults
2. American Diabetes Association, Diabetes Care, 2026 -- Diagnosis and Classification of Diabetes
3. The Menopause Society, 2026 -- Diabetes Risk Not Associated With Timing or Type of Menopause
4. Frontiers in Endocrinology — High triglyceride–glucose index and changes in triglyceride–glucose index are associated with an increased risk of hypogonadism in middle-aged Taiwanese men: a retrospective longitudinal study
5. Frontiers in Endocrinology — Association of triglyceride-glucose-body mass index and diabetic retinopathy in Chinese elderly patients with type 2 diabetes: a cross-sectional retrospective study
6. Frontiers in Endocrinology — TyHGB and CVD high-risk stratification: nonlinear association and discrimination in the ChinaHEART Luohe study
7. Lipid biomarkers for the prediction of type 2 diabetes risk
8. 2. Diagnosis and Classification of Diabetes: Standards of Care in Diabetes—2026 | Diabetes Care | American Diabetes Association
9. Diabetes Risk Not Associated With Timing or Type of Menopause | The Menopause Society
10. Frontiers | Association between triglyceride-glucose and triglyceride glucose body mass index with risk of prediabetes: a multicenter Chinese medical examination cohort study
11. Frontiers | Linear associations of triglyceride-glucose body mass index and atherogenic index of plasma with the risk of diabetes: a retrospective cohort study
12. The triglyceride-glucose index as a biomarker of diabetic retinopathy: a systematic review and meta-analysis - PMC
13. Triglyceride-glucose index and cardiovascular disease by cardiovascular-kidney-metabolic syndrome and socioeconomic status among postmenopausal women - ScienceDirect