Prospective Real-World Assessment of Pain Relief with Injection-Based Delivery of Etoricoxib (RAPID Study) - Report - MDSpire
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Evaluation of Pain Management Efficacy Using Injectable Etoricoxib: Findings from the RAPID Study

  • By

  • Shiva Shankar Jha

  • Anoop Dhamangaonkar

  • Rajkumar Iyengar

  • Gautam Chakraverty

  • Kotini Saskar Rao

  • Abhijeet Mukherji

  • Sameer Muchhala

  • Vidhya Natarajan

  • August 22, 2026

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Clinical Report: Evaluation of Pain Management Efficacy Using Injectable Etoricoxib

Overview

The RAPID study demonstrated that intramuscular etoricoxib 90 mg significantly reduces pain within 60 minutes of administration, with effects lasting up to 24 hours. The treatment was generally well tolerated.

Background

Acute pain management remains a critical challenge in healthcare, particularly in settings where oral medications are impractical. Inadequate pain relief can lead to prolonged recovery times and increased healthcare costs.

Data Highlights

Across 68 Indian sites, hospitalized patients receiving intramuscular etoricoxib 90 mg experienced pain reduction within 60 min of injection, with the improvement persisting for up to 24 h.

Key Findings

  • Intramuscular etoricoxib 90 mg provided significant pain relief within 60 minutes.
  • Pain reduction effects lasted for up to 24 hours post-injection.
  • The treatment was generally well tolerated with few reported side effects.
  • Injectable etoricoxib may be particularly useful in situations where oral analgesics are impractical.
  • Previous studies have shown that oral etoricoxib is effective for postoperative pain management.

Clinical Implications

The findings indicate that injectable etoricoxib could be an alternative for managing acute pain in hospitalized patients when oral administration is not possible.

Conclusion

The RAPID study supports the use of intramuscular etoricoxib for acute pain management.

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  3. Drugs - Real World Outcomes, 2026 -- Evaluation of Safety and Efficacy of a Fixed-Dose Combination of Prolonged Release Pregabalin and Etoricoxib in Patients with Chronic Low Back Pain Featuring Neuropathic Symptoms: A Phase IV Multicenter Study
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  10. https://eusem.org/images/251210_EUSEM_European_Pain_Initiative_Guidelines_Updated_Oct_2025.pdf
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Original Source(s)

Prospective Real-World Assessment of Pain Relief with Injection-Based Delivery of Etoricoxib (RAPID Study)

  • by Shiva Shankar Jha, Anoop Dhamangaonkar, Rajkumar Iyengar, Gautam Chakraverty, Kotini Saskar Rao, Abhijeet Mukherji, Sameer Muchhala, Vidhya Natarajan

  • August 22, 2026

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