Psychological stress and diastolic blood pressure in cardiology outpatients: a multicenter cross-sectional study (from the ABC2X-2026 study) - Report - MDSpire

Psychological stress and diastolic blood pressure in cardiology outpatients: a multicenter cross-sectional study (from the ABC2X-2026 study)

  • By

  • Giuseppe Berton

  • Mattia Ludovico Dario

  • David Merotto

  • Rocco Cordiano

  • Elena Selvestrel

  • Silvia Rui

  • Heba Talat Mahmoud

  • June 17, 2026

  • 0 min

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Clinical Report: The Impact of Psychological Stress on Diastolic Blood Pressure

Overview

This multicenter study reveals that psychological stress is prevalent among cardiology outpatients and is independently associated with higher diastolic blood pressure (DBP), particularly in patients with coronary artery disease and older adults. The findings underscore the importance of assessing psychological stress in routine cardiovascular risk evaluations.

Background

Psychological stress is increasingly recognized as an independent risk factor for cardiovascular disease, influencing both the development and progression of hypertension. Current guidelines advocate for the integration of mental health assessments into cardiovascular care, highlighting the need for a comprehensive approach to patient management. Understanding the hemodynamic effects of stress can enhance risk stratification and inform treatment strategies in cardiology.

Data Highlights

ParameterFinding
Prevalence of Psychological Stress373 patients (55%) reported stress
Present Stress264 patients (39%)
Previous Stress109 patients (16%)
DBP Increase with Present Stressβ = 3.0 ± 0.9 mmHg, p = 0.001
DBP Increase in CAD Patientsβ = 5.9 ± 2.4 mmHg, p = 0.01

Key Findings

  • Psychological stress is reported by 55% of cardiology outpatients.
  • Present stress is linked to higher diastolic blood pressure (DBP) in patients.
  • Older age and coronary artery disease (CAD) amplify the DBP response to present stress.
  • Previous stress does not show a significant association with DBP or other hemodynamic parameters.
  • Routine assessment of psychological stress may enhance cardiovascular risk stratification.

Clinical Implications

Healthcare professionals should routinely assess psychological stress in cardiology outpatients to identify those at higher risk for elevated diastolic blood pressure. This approach may facilitate targeted interventions and improve overall cardiovascular management.

Conclusion

The study highlights the significant impact of ongoing psychological stress on diastolic blood pressure among cardiology outpatients, emphasizing the need for integrated mental health assessments in cardiovascular care.

Related Resources & Content

  1. European Journal of Preventive Cardiology, 2023 -- Links Between Psychosocial Stress and Prognostic Biomarkers in Individuals with Chronic Coronary Syndrome: Insights from a STABILITY Substudy
  2. npj Digital Medicine, 2025 -- Assessment of Two Simple Digital Breathing Techniques for Managing Daily Stress: Findings from the Anti-Stress Intervention Among Physicians (ASIP) N-of-1 Trials
  3. European Journal of Preventive Cardiology, 2023 -- Exercise-Induced Blood Pressure Variations in Men and Women Across Different Ages and Fitness Levels
  4. BMC Medicine, 2026 -- Pre-diagnostic biomarkers and risk of stress-related disorders: a cohort study based on electronic health records
  5. 2024 ESC Guidelines for Management of Elevated BP and Hypertension: Key Points - American College of Cardiology
  6. Physiological and psychological responses to acute stress: A meta-analysis of the 171 studies of Trier Social Stress Test including 8452 healthy adults - ScienceDirect
  7. 2024 ESC Guidelines for Management of Elevated BP and Hypertension: Key Points - American College of Cardiology
  8. Physiological and psychological responses to acute stress: A meta-analysis of the 171 studies of Trier Social Stress Test including 8452 healthy adults - ScienceDirect

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