Clinical Report: Impact of Multi-Immunonutrient-Enriched Enteral Immunonutrition

Overview

This systematic review and meta-analysis evaluated the efficacy of enteral immunonutrition (EIN) versus standard enteral nutrition (EN) in patients post-gastric cancer surgery. Findings indicate that EIN significantly reduces infectious complications, total complications, and length of hospital stay while improving immune parameters.

Background

Gastric cancer is a prevalent malignancy associated with high morbidity and mortality rates. Patients often experience malnutrition due to the disease and surgical interventions, which can exacerbate postoperative complications. Enteral immunonutrition, which includes immunomodulatory nutrients, may enhance recovery and improve clinical outcomes in this vulnerable population.

Data Highlights

Key Findings

• EIN significantly reduced the incidence of infectious complications (OR = 0.48).
• EIN shortened the length of hospital stay by an average of 1.24 days (MD = −1.24 days).
• Improved immune parameters were observed with EIN, including increased levels of IgG, IgM, and IgA.
• Subgroup analysis indicated that perioperative administration of EIN yielded the most significant benefits.
• Intervention durations greater than 7 days showed superior outcomes.

Clinical Implications

Perioperative enteral immunonutrition may be beneficial for patients undergoing gastric cancer surgery, particularly those at nutritional risk. Individualized assessment is essential to determine the appropriateness of EIN in clinical practice.

Conclusion

The findings suggest that perioperative EIN can lead to improved clinical outcomes in gastric cancer surgery patients, warranting further investigation in larger trials.

Related Resources & Content

1. Author(s)/Org, Source, Year -- Title
2. Author(s)/Org, Source, Year -- Title
3. Author(s)/Org, Source, Year -- Title
4. Author(s)/Org, Source, Year -- Title
5. Author(s)/Org, Source, Year -- Title
6. Enhanced outpatient nutritional interventions lead to improved weight and muscle preservation following esophageal cancer surgery: a retrospective, single-center study.
7. ESPEN guideline on clinical nutrition in surgery – Update 2025
8. Effect of perioperative immunonutrition on outcomes in gastric cancer surgery patients
9. n-3 PUFA-supplemented perioperative immunonutrition on postoperative outcomes in gastric cancer: a systematic review and meta-analysis - PMC
10. Perioperative Oral Immunonutrient Regulation of Intestinal Barrier and Gut Microbiota in Patients with Gastric Cancer, a Randomized Controlled Clinical Trial | MDPI
11. ESPEN guideline on clinical nutrition in surgery – Update 2025 - Clinical Nutrition