Pharmacotherapy, acupoint stimulation, and psychotherapy for perimenopausal women with anxiety, depression, and panic disorder: a systematic review and network meta-analysis of randomized controlled trials - Report - MDSpire
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Pharmacotherapy, acupoint stimulation, and psychotherapy for perimenopausal women with anxiety, depression, and panic disorder: a systematic review and network meta-analysis of randomized controlled trials
Clinical Report: Comparative Efficacy of Treatments for Perimenopausal Disorders
Overview
This systematic review and network meta-analysis evaluated the efficacy of pharmacotherapy, acupoint stimulation, and psychotherapy in treating anxiety, depression, and panic disorders in perimenopausal women.
Background
Perimenopausal women often experience significant psychological symptoms due to hormonal changes, which can lead to anxiety, depression, and panic disorders. Current interventions include pharmacotherapy, acupoint stimulation, and psychotherapy, each with varying degrees of effectiveness and safety.
Data Highlights
Intervention
SUCRA (Efficacy)
Outcome
Drug_Psych
92.4%
HAMD
AcuStim_Psych
93.7%
HAMA
Psych
98.9%
SAS
Drug_AcuStim
9.0%
Clinical Efficacy
Control
65.5%
Safety Outcomes
Key Findings
131 RCTs involving 11,457 perimenopausal women were included in the analysis.
Pharmacotherapy combined with psychotherapy had the highest SUCRA probabilities for various scales measuring depression and anxiety.
Antidepressants combined with Traditional Chinese Medicine ranked highest for HAMD and safety outcomes.
No single treatment strategy was consistently superior across all outcomes.
Clinical Implications
The findings suggest that clinicians should consider combination therapies for treating emotional disorders in perimenopausal women, as they may provide enhanced efficacy. Individualized treatment plans should be developed based on patients' specific clinical characteristics and therapeutic goals.
Conclusion
This analysis highlights the therapeutic benefits of pharmacological, acupoint stimulation, and psychological interventions for perimenopausal women with emotional disorders.
