Impact of cognitive impairment on postoperative delirium and discharge disposition following knee arthroplasty: a Japanese nationwide propensity score–matched study - Report - MDSpire
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Effects of Cognitive Dysfunction on Postoperative Delirium and Discharge Outcomes After Knee Arthroplasty: A Nationwide Propensity Score-Matched Analysis from Japan

  • By

  • Yu Mori

  • Kunio Tarasawa

  • Hidetatsu Tanaka

  • Ryuichi Kanabuchi

  • Naoko Mori

  • Kiyohide Fushimi

  • Toshimi Aizawa

  • Kenji Fujimori

  • August 14, 2026

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Clinical Report: Effects of Cognitive Dysfunction on Postoperative Delirium

Overview

This study investigates the impact of cognitive impairment on postoperative delirium in older patients undergoing total knee arthroplasty (TKA) in Japan. Findings indicate that cognitive dysfunction is associated with increased risk of delirium.

Background

As Japan's elderly population grows, the number of older individuals undergoing orthopedic surgeries like TKA is rising. Postoperative delirium is a common complication that can lead to longer hospital stays and poorer recovery outcomes.

Data Highlights

No specific numerical data or trial data provided in the source material.

Key Findings

  • Cognitive impairment is linked to a higher risk of postoperative delirium in older patients undergoing TKA.
  • Patients with cognitive dysfunction have a lower probability of being discharged directly to their homes.
  • The study utilized a nationwide database, enhancing the robustness of the findings.
  • Postoperative delirium can lead to extended hospital stays and increased healthcare costs.
  • Comorbidities and frailty are prevalent in the elderly population undergoing TKA.

Clinical Implications

Healthcare providers should consider cognitive status when planning perioperative care for older patients undergoing TKA. Enhanced monitoring and tailored management strategies may be necessary to mitigate the risk of postoperative delirium.

Conclusion

Cognitive impairment significantly affects postoperative outcomes in older adults undergoing knee arthroplasty.

Related Resources & Content

  1. MDSpire News, 2023 -- Preop Cognitive Impairment Tied to TKA Delirium
  2. Elevated Incidence of Deep Vein Thrombosis and Surgical Site Infections Following Cemented Total Knee Arthroplasty: A Nationwide Propensity Score-Matched Analysis in Japan, 2023
  3. Frontiers in Neurology, 2026 -- Prediction models for postoperative cognitive dysfunction in adults: a systematic review of methodological quality and clinical applicability
  4. Utilization of Computer-Assisted Techniques in Total Hip Arthroplasty Lowers Early Complication Rates According to Nationwide Medical Claims Data from Japan
  5. American Psychiatric Association Publishes Updated Comprehensive Guideline for the Prevention and Treatment of Delirium
  6. Updated ESAIC guidelines on postoperative delirium in adults
  7. Overview | Delirium: prevention, diagnosis and management in hospital and long-term care
  8. Effectiveness of drug interventions to prevent delirium after surgery for older adults: systematic review and network meta-analysis of randomised controlled trials | The BMJ
  9. Perioperative interventions in preventing postoperative delirium following orthopaedic surgery in the elderly: a Bayesian network meta-analysis - PubMed
  10. Postoperative Delirium in Older Adults Undergoing Noncardiac Surgery | Surgery | JAMA Network Open | JAMA Network
  11. Impact of Dementia on Perioperative Complications in Elderly Patients Undergoing Total Knee Arthroplasty: A Retrospective National Inpatient Sample Database Study - PubMed
  12. Cognitive Impairment and Postoperative Outcomes in Patients Undergoing Primary Total Hip Arthroplasty and Primary Total Knee Arthroplasty: A Systematic Review and Meta-analysis - PubMed
  13. Increased risk of deep vein thrombosis and post-operative delirium following total knee arthroplasty compared with unicompartmental knee arthroplasty in patients aged 80 years and older: A nationwide Japanese medical claims-based propensity score-matched study - ScienceDirect

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