Case report and literature review: key clinical management points and prognostic analysis of paraganglioma of the urinary bladder - Report - MDSpire

Case report and literature review: key clinical management points and prognostic analysis of paraganglioma of the urinary bladder

  • By

  • Chengbin Lu

  • Benmo Xu

  • Can Li

  • Sinan Yang

  • Xusong Pang

  • Weixiang Yang

  • Tianjian Xie

  • Zongyan Luo

  • Hanbin Li

  • Wei Luo

  • Zhiyu Shi

  • Libo Yang

  • Yong Yang

  • June 24, 2026

  • 0 min

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Clinical Report: Insights and Prognostic Evaluation of Bladder Paraganglioma

Background

Bladder paraganglioma is a rare neuroendocrine tumor, accounting for only 0.3%–1.0% of all paragangliomas. Its clinical symptoms are often nonspecific, leading to a high rate of misdiagnosis. Early diagnosis and appropriate management are crucial to minimize surgical complications and improve prognosis. The preoperative misdiagnosis rate exceeds 60%.

Data Highlights

No numerical data available.

Key Findings

  • The patient exhibited paroxysmal hypertension during urination, with peak blood pressure reaching 205/120 mmHg.
  • Diagnostic tests revealed elevated plasma levels of norepinephrine and methoxy norepinephrine.
  • Pelvic MRI showed a mass on the right bladder wall with hydronephrosis and suspicious pelvic lymph nodes.
  • Postoperative pathology confirmed bladder paraganglioma invading the full thickness of the bladder detrusor muscle.
  • No lymph node metastasis was observed in the examined lymph nodes.
  • During a 5-month follow-up, no recurrence or metastasis was detected.

Clinical Implications

Preoperative catecholamine metabolite testing and pelvic MRI are essential for diagnosing bladder paraganglioma.

Conclusion

Bladder paraganglioma requires careful diagnostic and surgical planning.

Related Resources & Content

  1. Liu et al., 2025 -- Comparative Analysis of Clinical Features and Treatment Approaches for Pre- and Postoperative Diagnoses of Urinary Bladder Paraganglioma
  2. The Journal of Clinical Endocrinology & Metabolism, 2025 -- Evaluating Pediatric Patients with Potential Pheochromocytoma or Paraganglioma in Comparison to Neuroblastoma
  3. Frontiers in Oncology, 2026 -- A Case Report of Primary Mucinous Adenocarcinoma of the Bladder and Literature Review
  4. Frontiers in Oncology — Bladder sarcoma treated with radical cystectomy and adjuvant epirubicin and ifosfamide chemotherapy: a case report
  5. NCCN Guidelines for Pheochromocytomas and Paragangliomas

Original Source(s)

Case report and literature review: key clinical management points and prognostic analysis of paraganglioma of the urinary bladder

  • by Chengbin Lu, Benmo Xu, Can Li, Sinan Yang, Xusong Pang, Weixiang Yang, Tianjian Xie, Zongyan Luo, Hanbin Li, Wei Luo, Zhiyu Shi, Libo Yang, Yong Yang

  • June 24, 2026

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