Determinants of Influenza Vaccine Reluctance in Cancer Patients: A Multicenter Cross-Sectional Analysis Utilizing the Health Belief Model - Report - MDSpire

Determinants of Influenza Vaccine Reluctance in Cancer Patients: A Multicenter Cross-Sectional Analysis Utilizing the Health Belief Model

  • By

  • Qinghua Dong

  • Yiwei Luo

  • Xiaoyu Tang

  • Minye Li

  • Dianjie Chen

  • Zhengji He

  • Qun Xiao

  • Chen Zhi

  • Min Zhu

  • Hui Ma

  • January 24, 2026

  • 0 min

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Determinants of Influenza Vaccine Reluctance in Cancer Patients

Overview

This study investigates the factors contributing to influenza vaccine hesitancy among cancer patients using the Health Belief Model. Despite the high risk of severe influenza complications in this population, vaccination rates remain low, highlighting a critical public health concern.

Background

Influenza poses a significant health risk, particularly for cancer patients who have compromised immune systems. Vaccination is crucial for this group, as it can reduce both infection rates and mortality. However, vaccine uptake among cancer patients is notably lower than in the general population, necessitating an exploration of the underlying reasons for this hesitancy.

Data Highlights

No numerical data available in the source material.

Key Findings

  • Cancer patients are at a higher risk for severe influenza complications compared to healthy individuals.
  • Influenza vaccination can reduce total mortality in cancer patients by 9% to 34%.
  • Vaccine hesitancy among cancer survivors in China is as high as 42.06%.
  • Vaccination rates for cancer patients are significantly lower than for patients with other chronic conditions.
  • Utilizing the Health Belief Model can help identify factors influencing vaccine acceptance.

Clinical Implications

Healthcare providers should prioritize addressing vaccine hesitancy among cancer patients by improving communication about the benefits and safety of influenza vaccination. Tailored interventions based on the Health Belief Model may enhance vaccination rates in this vulnerable population.

Conclusion

Addressing the determinants of vaccine hesitancy in cancer patients is essential for improving influenza vaccination rates and ultimately enhancing patient outcomes. Further research and targeted strategies are needed to bridge this immunization gap.

References

  1. American Society of Clinical Oncology, ASCO Post, 2022 -- Why Some Patients With Cancer Are Reluctant to Receive COVID-19 Vaccination
  2. American Society of Clinical Oncology, ASCO Post, 2022 -- Communication Is Key to Overcoming Resistance to COVID-19 Vaccination
  3. Open Forum Infectious Diseases, 2021 -- Determinants of Vaccine Acceptance for Pneumococcal, COVID-19, and Influenza Among Individuals with HIV in Belgium
  4. American Journal of Epidemiology, 2022 -- Attributable Impact of Vaccine Hesitancy on Nonvaccination and Undervaccination Rates for COVID-19 in 2022
  5. ACIP Recommendations Summary | Influenza (Flu) | CDC, 2025
  6. CDC, 2024 -- Interim Estimates of 2024–2025 Seasonal Influenza Vaccine Effectiveness
  7. Factors influencing influenza vaccine hesitancy among cancer patients: a multicenter cross-sectional study based on the Health Belief Model - PMC
  8. ACIP Recommendations Summary | Influenza (Flu) | CDC
  9. Interim Estimates of 2024–2025 Seasonal Influenza Vaccine Effectiveness — Four Vaccine Effectiveness Networks, United States, October 2024–February 2025 | MMWR
  10. Factors influencing influenza vaccine hesitancy among cancer patients: a multicenter cross-sectional study based on the Health Belief Model - PMC

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