Chlorine inhalation-induced ARDS treated with noninvasive ventilation and awake prone positioning: a case report - Report - MDSpire
Coming Soon: Introducing MDSpire News. Learn more
Conexiant’s news site is now MDSpire News. Learn more

Management of Chlorine-Induced Acute Respiratory Distress Syndrome with Noninvasive Ventilation and Prone Positioning: A Case Study

  • By

  • Yu E. Xue

  • Jianyue Zhang

  • Zanfeng Cao

  • Zuopeng Zhang

  • September 9, 2026

Share

Management of Chlorine-Induced Acute Respiratory Distress Syndrome

Overview

This case study presents a 76-year-old man who developed acute respiratory distress syndrome (ARDS) due to chlorine inhalation. Management included noninvasive ventilation and awake prone positioning, leading to complete recovery.

Background

Chlorine gas exposure is a significant public health concern, particularly in environments using chlorine-containing disinfectants. High-concentration exposure can lead to severe respiratory complications, including ARDS. Understanding effective management strategies is crucial for improving patient outcomes in such cases.

Data Highlights

ParameterValue
PaO2/FiO2 ratio184 mmHg
PEEP5 cmH₂O
NT-proBNP222 pg/mL

Key Findings

  • The patient developed ARDS after inhaling chlorine gas from a disinfectant.
  • At admission, the PaO2/FiO2 ratio was 184 mmHg, indicating moderate ARDS.
  • Noninvasive mechanical ventilation and awake prone positioning were employed successfully.
  • Complete recovery was achieved with comprehensive supportive care.
  • Chlorine poisoning lacks a specific antidote, necessitating supportive treatment.

Clinical Implications

This case highlights the need for early recognition and supportive treatment in chlorine-induced ARDS.

Conclusion

The management of this case demonstrates the use of noninvasive strategies in treating ARDS due to chlorine exposure.

Related Resources & Content

  1. Critical Care (Springer), 2025 -- Effectiveness and safety of prolonged prone positioning in adult patients with acute respiratory distress syndrome (ARDS): a systematic review and meta-analysis
  2. Critical Care (Springer), 2025 -- Predicting early prone position ventilation responsiveness in patients with acute respiratory distress syndrome based on electrical impedance tomography: a prospective study
  3. Intensive Care Medicine, 2026 -- Acute hypoxemic respiratory failure: from static severity to trajectory-based phenotyping
  4. Intensive Care Medicine, 2026 -- Prone positioning in ARDS
  5. Chlorine | Chemical Emergencies | CDC, 2026 -- Chlorine gas exposure management
  6. American Journal of Respiratory and Critical Care Medicine, 2023 -- Official ATS/ESICM/SCCM Clinical Practice Guideline: Mechanical Ventilation in Adult Patients with Acute Respiratory Distress Syndrome
  7. American Journal of Respiratory and Critical Care Medicine, 2026 -- Noninvasive respiratory support for adult patients with acute respiratory failure: an official ATS Clinical Practice Guideline
  8. Chlorine | Chemical Emergencies | CDC
  9. Official American Thoracic Society/European Society of Intensive Care Medicine/Society of Critical Care Medicine Clinical Practice Guideline: Mechanical Ventilation in Adult Patients with Acute Respiratory Distress Syndrome | American Journal of Respiratory and Critical Care Medicine | Oxford Academic
  10. Noninvasive respiratory support for adult patients with acute respiratory failure: an official American Thoracic Society Clinical Practice Guideline | American Journal of Respiratory and Critical Care Medicine | Oxford Academic

Original Source(s)

Related Content